HitPredict

Interactor 1: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Interactor 2: STX12 (Q86Y82)
Syntaxin-12
Gene: STX12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.929

Property	Details
Experiments	26186194, 28514442, 33961781, unassigned3799, 17159904
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, x-ray crystallography, circular dichroism, molecular sieving, comigration in non denaturing gel electrophoresis
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0000139 - Golgi membrane GO:0005794 - Golgi apparatus GO:0031201 - SNARE complex GO:0032456 - endocytic recycling GO:0045335 - phagocytic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 141 Hs			1 276
+	Hs
		278503 VAMP4_HUMAN (1-120): 6.5e-39: 129: 100.00		STX1A_HUMAN (17-273): 6.84e-67: 211: 23.19
+	At
		1457275 VA721_ARATH (6-140): 2.32e-44: 146: 30.37		SYP42_ARATH (2-273): 1.6e-59: 193: 21.79
+	At
		1492011 VA721_ARATH (6-140): 2.32e-44: 146: 30.37		SY121_ARATH (8-252): 2.97e-59: 193: 18.75
+	At
		1020624 VA721_ARATH (6-140): 2.32e-44: 146: 30.37		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	At
		265751 VA721_ARATH (6-140): 2.32e-44: 146: 30.37		SYP41_ARATH (2-273): 4.64e-58: 189: 21.07
+	At
		866336 VA722_ARATH (6-139): 1.01e-42: 142: 32.09		SY121_ARATH (8-252): 2.97e-59: 193: 18.75
+	At
		1457227 VA721_ARATH (6-140): 2.32e-44: 146: 30.37		SY122_ARATH (1-252): 6.95e-57: 187: 20.53
+	Dm
		1174524 Q7JYX5_DROME (15-138): 3.31e-37: 127: 27.42		STX1A_DROME (4-273): 6.42e-64: 204: 22.10
+	At
		1457166 VA721_ARATH (6-140): 2.32e-44: 146: 30.37		SYP43_ARATH (2-273): 2.12e-55: 183: 20.00
+	At
		1020603 VA713_ARATH (7-138): 5.01e-41: 137: 25.76		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	At
		1020601 VA714_ARATH (7-138): 9.83e-39: 132: 27.27		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	At
		1192502 VA721_ARATH (6-140): 2.32e-44: 146: 30.37		SY111_ARATH (4-252): 1.65e-51: 172: 19.77
+	At
		235605 VA711_ARATH (7-138): 7.99e-37: 127: 23.49		SYP22_ARATH (1-258): 1.52e-59: 191: 24.43
+	Hs
		160854 VAMP4_HUMAN (1-120): 6.5e-39: 129: 100.00		STX16_HUMAN (6-250): 1.61e-56: 186: 25.00
+	At
		866323 VA722_ARATH (6-139): 1.01e-42: 142: 32.09		SY111_ARATH (4-252): 1.65e-51: 172: 19.77
+	Hs
		189346 VAMP4_HUMAN (1-120): 6.5e-39: 129: 100.00		STX7_HUMAN (8-272): 1.12e-55: 181: 51.70
+	At
		235607 VA711_ARATH (7-138): 7.99e-37: 127: 23.49		SYP21_ARATH (1-258): 7.67e-55: 180: 27.88
+	Hs
		278494 VAMP4_HUMAN (1-120): 6.5e-39: 129: 100.00		STX4_HUMAN (6-272): 1.26e-53: 177: 24.27
+	Hs
		278497 VAMP4_HUMAN (1-120): 6.5e-39: 129: 100.00		STX3_HUMAN (5-250): 2.57e-53: 176: 25.20
+	At
		1355121 VA721_ARATH (6-140): 2.32e-44: 146: 30.37		SY132_ARATH (107-252): 5.36e-12: 66.6: 32.88