HitPredict

Interactor 1: ERN1 (O75460)
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
Gene: ERN1

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	40437099
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0042803 - protein homodimerization activity GO:0051082 - unfolded protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 977 Hs			1 724
+	Hs
		282557 ERN1_HUMAN (1-963): 0: 918: 100.00		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		573541 ERN2_HUMAN (2-970): 0: 820: 48.20		ENPL_HUMAN (3-693): 0: 914: 46.44
+	Hs
		468288 KPCT_HUMAN (322-898): 7.48e-134: 421: 16.69		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		461385 KPCT_HUMAN (322-898): 7.48e-134: 421: 16.69		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Rn
		479891 KPCD_RAT (327-902): 1.75e-129: 408: 16.30		HS90A_RAT (1-724): 0: 1066: 84.45
+	Sc
		392401 IRE1_YEAST (32-964): 3.58e-172: 533: 24.02		HSP82_YEAST (12-724): 0: 925: 61.26
+	Hs
		468348 KCC2D_HUMAN (569-963): 1.15e-118: 374: 21.48		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		468926 KCC2A_HUMAN (569-969): 2.37e-117: 369: 20.20		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		461452 KCC2D_HUMAN (569-963): 1.15e-118: 374: 21.48		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		462055 KCC2A_HUMAN (569-969): 2.37e-117: 369: 20.20		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		468396 KS6A2_HUMAN (570-873): 1.04e-67: 243: 22.26		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		468200 KS6A3_HUMAN (570-873): 3.7e-66: 238: 20.69		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		468894 KS6A6_HUMAN (570-873): 1.15e-63: 231: 20.19		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		461502 KS6A2_HUMAN (570-873): 1.04e-67: 243: 22.26		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		468399 KS6A1_HUMAN (570-873): 6.37e-63: 229: 20.38		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		461291 KS6A3_HUMAN (570-873): 3.7e-66: 238: 20.69		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		462023 KS6A6_HUMAN (570-873): 1.15e-63: 231: 20.19		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		461505 KS6A1_HUMAN (570-873): 6.37e-63: 229: 20.38		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Zm
		24174 A0A1D6ICZ3_MAIZE (494-977): 5.36e-134: 415: 15.63		A0A1D6LMW9_MAIZE (5-693): 0: 849: 46.66
+	Hs
		461451 KCC2G_HUMAN (610-831): 3.26e-18: 91.3: 29.31		HS90A_HUMAN (1-724): 0: 1069: 85.25