Protein: IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]

Gene: IRE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 155
UniProt ID: P32361

Gene Ontology (top 5):
GO:0004521 - RNA endonuclease activity
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

735468

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

12

17

Small-scale

0.983

High

577065

SEC63
Protein translocation protein SEC63

2

4

Small-scale

0.737

High

597068

BIP
Endoplasmic reticulum chaperone BiP

7

11

Small-scale

0.736

High

735500

PP2C2
Protein phosphatase 2C homolog 2

1

10

Small-scale

0.709

High

735537

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

7

High-throughput

0.656

High

694112

CDC15
Cell division control protein 15

1

18

High-throughput

0.647

High

735479

PP2C1
Protein phosphatase 2C homolog 1

1

9

High-throughput

0.647

High

735481

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

18

High-throughput

0.647

High

735518

AZF1
Transcription factor AZF1

1

2

High-throughput

0.647

High

735530

FPK1
Flippase kinase 1

1

6

High-throughput

0.647

High

735582

YP150
Putative serine/threonine-protein kinase YPL150W

1

17

High-throughput

0.647

High

366044

CBPY
Carboxypeptidase Y

2

3

Small-scale

0.624

High

464571

PBS2
MAP kinase kinase PBS2

1

18

High-throughput

0.618

High

735477

PIN4
RNA-binding protein PIN4

1

1

High-throughput

0.618

High

735490

RCK2
Serine/threonine-protein kinase RCK2

1

18

High-throughput

0.618

High

735511

FKH1
Fork head protein homolog 1

1

3

High-throughput

0.618

High

735547

TDA1
Serine/threonine-protein kinase TDA1

1

19

High-throughput

0.618

High

735590

SKM1
Serine/threonine-protein kinase SKM1

1

17

High-throughput

0.618

High

735501

ARB1
ABC transporter ATP-binding protein ARB1

1

0

High-throughput

0.614

High

735594

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.614

High

735560

RRP5
rRNA biogenesis protein RRP5

1

5

High-throughput

0.579

High

392401

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.575

High

735515

DJP1
DnaJ-like protein 1

1

6

High-throughput

0.575

High

735546

GCN5
Histone acetyltransferase GCN5

1

6

Small-scale

0.573

High

544141

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.571

High

735505

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.571

High

735563

DCR2
Phosphatase DCR2

1

0

Small-scale

0.561

High

735577

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

0

High-throughput

0.541

High

735507

SECU
Securin

1

1

High-throughput

0.536

High

554320

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.518

High

455556

SYSC
Serine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

664261

SSD1
Protein SSD1

1

3

High-throughput

0.501

High

734510

MSB2
Signaling mucin MSB2

1

8

Small-scale

0.501

High

735469

PAH1
Phosphatidic acid phosphohydrolase 1

1

1

High-throughput

0.501

High

735472

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

4

High-throughput

0.501

High

735475

SGE1
Protein SGE1

1

8

High-throughput

0.501

High

735498

HPH2
Protein HPH2

1

1

High-throughput

0.501

High

735520

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

735525

PHO23
Transcriptional regulatory protein PHO23

1

3

High-throughput

0.501

High

735526

SKP1
Suppressor of kinetochore protein 1

1

4

High-throughput

0.501

High

735541

TBF1
Protein TBF1

1

1

High-throughput

0.501

High

735572

NVJ2
Nucleus-vacuole junction protein 2

1

1

High-throughput

0.501

High

735575

BDF2
Bromodomain-containing factor 2

1

5

High-throughput

0.501

High

735581

SAS10
Something about silencing protein 10

1

1

High-throughput

0.501

High

735580

HOSM
Homocitrate synthase, mitochondrial

1

0

High-throughput

0.493

High

735555

ZWINT
Outer kinetochore KNL1 complex subunit KRE28

1

0

High-throughput

0.486

High

584899

TRM1
tRNA

1

0

High-throughput

0.480

High

647041

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.480

High

735485

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.480

High

735487

YB47
Uncharacterized protein YBR197C

1

0

High-throughput

0.480

High

735519

PRM10
Pheromone-regulated membrane protein 10

1

0

High-throughput

0.480

High

735524

SPT20
SAGA complex subunit SPT20

1

0

Small-scale

0.480

High

735531

SQS1
Protein SQS1

1

0

High-throughput

0.480

High

735532

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.480

High

735540

ADA2
SAGA complex subunit ADA2

1

0

Small-scale

0.480

High

735542

RNT1
Ribonuclease 3

1

0

High-throughput

0.480

High

735552

YAP6
AP-1-like transcription factor YAP6

1

0

High-throughput

0.480

High

735578

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.480

High

735583

YRR1
Zinc finger transcription factor YRR1

1

0

High-throughput

0.480

High

554114

BAR1
Barrierpepsin

1

1

High-throughput

0.479

High

657957

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

5

High-throughput

0.479

High

682202

SPB4
ATP-dependent rRNA helicase SPB4

1

6

High-throughput

0.479

High

735474

SC61A
Protein transport protein SEC61

1

3

High-throughput

0.479

High

735484

RDH54
DNA repair and recombination protein RDH54

1

2

High-throughput

0.479

High

735503

DOT6
Transcriptional regulatory protein DOT6

1

1

High-throughput

0.479

High

735509

NDC80
Kinetochore protein NDC80

1

13

High-throughput

0.479

High

735517

NOP2
25S rRNA

1

2

High-throughput

0.479

High

735529

PAP2
Poly(A) RNA polymerase protein 2

1

1

High-throughput

0.479

High

735551

ARX1
Probable metalloprotease ARX1

1

1

High-throughput

0.479

High

735564

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

12

High-throughput

0.479

High

735565

DUS3
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]

1

2

High-throughput

0.479

High

735584

RLM1
Transcription factor RLM1

1

1

High-throughput

0.479

High

735585

RIB2
Bifunctional protein RIB2 [Includes: tRNA pseudouridine(32) synthase, cytoplasmic

1

2

High-throughput

0.479

High

564648

STE12
Protein STE12

1

0

High-throughput

0.458

High

735476

MKS1
Negative regulator of RAS-cAMP pathway

1

0

High-throughput

0.458

High

735504

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

735513

VID28
GID complex subunit 5

1

0

High-throughput

0.458

High

735527

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.458

High

735528

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

735535

DAK1
Dihydroxyacetone kinase 1

1

0

High-throughput

0.458

High

735538

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.458

High

735567

LCB5
Sphingoid long chain base kinase 5

1

0

High-throughput

0.458

High

735568

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

735574

SYO1
Synchronized import protein 1

1

0

High-throughput

0.458

High

735579

AEP3
ATPase expression protein 3

1

0

High-throughput

0.458

High

504669

YL21A
Transposon Ty2-LR1 Gag polyprotein

1

10

High-throughput

0.457

High

514934

YA11A
Transposon Ty1-A Gag polyprotein

1

9

High-throughput

0.457

High

514995

YE11A
Transposon Ty1-ER1 Gag polyprotein

1

8

High-throughput

0.457

High

600665

SEC2
Rab guanine nucleotide exchange factor SEC2

1

1

High-throughput

0.457

High

663309

FPS1
Glycerol uptake/efflux facilitator protein

1

11

High-throughput

0.457

High

732023

MLF3
Protein MLF3

1

2

High-throughput

0.457

High

735478

PRX1
Peroxiredoxin PRX1, mitochondrial

1

7

High-throughput

0.457

High

735480

ATG19
Autophagy-related protein 19

1

1

High-throughput

0.457

High

735483

VBA5
Vacuolar basic amino acid transporter 5

1

7

High-throughput

0.457

High

735486

AIM3
Altered inheritance of mitochondria protein 3

1

5

High-throughput

0.457

High

735491

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

8

High-throughput

0.457

High

735493

ARN2
Siderophore iron transporter ARN2

1

6

High-throughput

0.457

High

735499

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.457

High

735508

VPS27
Vacuolar protein sorting-associated protein 27

1

2

High-throughput

0.457

High

735510

VHS2
Protein VHS2

1

2

High-throughput

0.457

High

735534

AQR1
Probable transporter AQR1

1

6

High-throughput

0.457

High

735548

YM8V
Uncharacterized protein YMR295C

1

1

High-throughput

0.457

High

735553

YM13A
Transposon Ty1-MR1 Gag polyprotein

1

10

High-throughput

0.457

High

735556

HSP31
Glutathione-independent glyoxalase HSP31

1

1

High-throughput

0.457

High

735559

YM11A
Transposon Ty1-ML1 Gag polyprotein

1

8

High-throughput

0.457

High

735561

HEL2
E3 ubiquitin-protein ligase HEL2

1

1

High-throughput

0.457

High

735566

YL257
Uncharacterized protein YLR257W

1

1

High-throughput

0.457

High

735569

CORO
Coronin-like protein

1

3

High-throughput

0.457

High

735570

TPO3
Polyamine transporter 3

1

6

High-throughput

0.457

High

735576

HSP33
Probable glutathione-independent glyoxalase HSP33

1

1

High-throughput

0.457

High

735586

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

7

High-throughput

0.457

High

735587

YD21A
Transposon Ty2-DR1 Gag polyprotein

1

11

High-throughput

0.457

High

735588

ISA2
Iron-sulfur assembly protein 2

1

1

High-throughput

0.457

High

735589

LAS17
Proline-rich protein LAS17

1

3

High-throughput

0.457

High

735591

YN12A
Transposon Ty1-NL2 Gag polyprotein

1

8

High-throughput

0.457

High

735592

YP14A
Transposon Ty1-PR3 Gag polyprotein

1

8

High-throughput

0.457

High

735593

YO11A
Transposon Ty1-OL Gag polyprotein

1

8

High-throughput

0.457

High

735539

UBC7
Ubiquitin-conjugating enzyme E2 7

1

8

High-throughput

0.457

High

481529

HSP73
Heat shock protein SSA3

1

9

High-throughput

0.445

High

653837

HSP12
12 kDa heat shock protein

1

1

High-throughput

0.445

High

735470

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

735471

HSP79
Heat shock protein homolog SSE2

1

14

High-throughput

0.445

High

735495

SSZ1
Ribosome-associated complex subunit SSZ1

1

7

High-throughput

0.445

High

735533

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.445

High

735571

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.445

High

430806

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

2

High-throughput

0.437

High

735473

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

1

High-throughput

0.437

High

735497

YH02
Uncharacterized protein YHR202W

1

1

High-throughput

0.437

High

735514

AIM21
Altered inheritance of mitochondria protein 21

1

3

High-throughput

0.437

High

735516

CBF3B
Centromere DNA-binding protein complex CBF3 subunit B

1

1

High-throughput

0.437

High

735549

CEF1
Pre-mRNA-splicing factor CEF1

1

8

High-throughput

0.437

High

735562

ENT2
Epsin-2

1

1

High-throughput

0.437

High

735557

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.426

High

464504

CHS1
Chitin synthase 1

1

0

High-throughput

0.261

Low

735489

YB8A
Putative uncharacterized protein YBR285W

1

0

High-throughput

0.261

Low

735496

BZZ1
Protein BZZ1

1

0

High-throughput

0.261

Low

735506

SIP5
Protein SIP5

1

0

High-throughput

0.261

Low

735521

IRC8
Uncharacterized protein IRC8

1

0

High-throughput

0.261

Low

735523

YD186
Uncharacterized protein YDL186W

1

0

High-throughput

0.261

Low

735536

AIM11
Altered inheritance of mitochondria protein 11

1

0

High-throughput

0.261

Low

735545

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

1

0

High-throughput

0.261

Low

735550

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.261

Low

735573

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.261

Low

735482

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

735488

YB9F
Uncharacterized protein YBR259W

1

0

High-throughput

0.249

Low

735492

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.249

Low

735494

OCA5
Oxidant-induced cell-cycle arrest protein 5

1

0

High-throughput

0.249

Low

735502

MRX1
MIOREX complex component 1

1

0

High-throughput

0.249

Low

735512

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.249

Low

735543

MUK1
Protein MUK1

1

0

High-throughput

0.249

Low

735544

ATP25
ATPase synthesis protein 25, mitochondrial

1

0

High-throughput

0.249

Low

735554

SEG1
Eisosome protein SEG1

1

0

High-throughput

0.249

Low

735558

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.249

Low

735522

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025