Protein: ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]

Gene: ERN1
Organism: Homo sapiens
Interactions: 99
UniProt ID: O75460

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001935 - endothelial cell proliferation
GO:0004521 - RNA endonuclease activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005161 - platelet-derived growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

282548

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

4

18

Small-scale

0.929

High

282621

M3K5
Mitogen-activated protein kinase kinase kinase 5

2

18

Small-scale

0.754

High

282561

BIP
Endoplasmic reticulum chaperone BiP

6

12

Small-scale

0.728

High

282557

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.724

High

282575

SRPK2
SRSF protein kinase 2

1

18

High-throughput

0.710

High

282600

SYVN1
E3 ubiquitin-protein ligase synoviolin

4

5

Small-scale

0.691

High

282627

TAOK3
Serine/threonine-protein kinase TAO3

1

15

Small-scale

0.683

High

282580

TRAF2
TNF receptor-associated factor 2

4

10

Small-scale

0.683

High

282567

CDN1A
Cyclin-dependent kinase inhibitor 1

1

5

High-throughput

0.665

High

282614

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.665

High

282609

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

3

High-throughput

0.628

High

282572

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

2

Small-scale

0.620

High

282612

CSN5
COP9 signalosome complex subunit 5

2

2

Small-scale

0.620

High

214360

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

Small-scale

0.618

High

240287

PRKN
E3 ubiquitin-protein ligase parkin

1

10

Small-scale

0.618

High

282558

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

282560

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

Small-scale

0.618

High

282584

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

7

Small-scale

0.618

High

282577

GABP1
GA-binding protein subunit beta-1

1

2

High-throughput

0.594

High

282590

ZN829
Zinc finger protein 829

1

2

High-throughput

0.594

High

282626

ZN341
Zinc finger protein 341

1

1

High-throughput

0.594

High

282632

SE1L1
Protein sel-1 homolog 1

2

2

Small-scale

0.594

High

282573

SC61B
Protein transport protein Sec61 subunit beta

2

0

Small-scale

0.585

High

282637

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

Small-scale

0.578

High

282633

SEC63
Translocation protein SEC63 homolog

1

2

Small-scale

0.575

High

282617

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

2

High-throughput

0.574

High

282556

PDIA1
Protein disulfide-isomerase

1

6

High-throughput

0.561

High

282594

PKHS1
Pleckstrin homology domain-containing family S member 1

1

0

High-throughput

0.556

High

282629

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.537

High

282606

TAFA2
Chemokine-like protein TAFA-2

1

1

High-throughput

0.536

High

282581

NMI
N-myc-interactor

1

0

Small-scale

0.529

High

155983

SOCS6
Suppressor of cytokine signaling 6

1

20

High-throughput

0.515

High

282568

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.515

High

282592

PKHG4
Puratrophin-1

1

10

High-throughput

0.515

High

282597

OTU7B
OTU domain-containing protein 7B

1

4

High-throughput

0.515

High

282602

TMTC1
Protein O-mannosyl-transferase TMTC1

1

5

High-throughput

0.515

High

282618

KAD8
Adenylate kinase 8

1

2

High-throughput

0.515

High

282628

CD209
CD209 antigen

1

1

High-throughput

0.515

High

282576

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.513

High

282587

ADIPO
Adiponectin

1

0

High-throughput

0.513

High

282593

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

282578

BAX
Apoptosis regulator BAX

1

2

Small-scale

0.501

High

193738

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.493

High

282549

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.493

High

282579

INCA1
Protein INCA1

1

0

High-throughput

0.493

High

282611

DPF1
Zinc finger protein neuro-d4

1

0

High-throughput

0.493

High

282622

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.493

High

282553

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.489

High

282562

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

1

High-throughput

0.489

High

282566

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

4

High-throughput

0.489

High

282589

CL12B
C-type lectin domain family 12 member B

1

1

High-throughput

0.489

High

282583

OS9
Protein OS-9

1

0

Small-scale

0.479

High

282613

YIPF5
Protein YIPF5

1

0

Small-scale

0.479

High

219577

B2L11
Bcl-2-like protein 11

1

1

Small-scale

0.479

High

220458

RNF13
E3 ubiquitin-protein ligase RNF13

1

3

Small-scale

0.479

High

282555

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

282559

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

5

Small-scale

0.479

High

282564

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

17

Small-scale

0.479

High

282586

PDIA6
Protein disulfide-isomerase A6

1

6

High-throughput

0.479

High

282620

DERL3
Derlin-3

1

1

Small-scale

0.479

High

282624

DERL1
Derlin-1

1

1

Small-scale

0.479

High

282635

XPO7
Exportin-7

1

4

High-throughput

0.479

High

282638

TRAF6
TNF receptor-associated factor 6

1

15

Small-scale

0.479

High

282598

Q6PHZ7
NR2C2 protein

1

7

High-throughput

0.470

High

282605

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

3

High-throughput

0.470

High

282631

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

5

High-throughput

0.470

High

282634

LAT2
Large neutral amino acids transporter small subunit 2

1

5

High-throughput

0.470

High

282563

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.458

High

282569

PSN1
Presenilin-1

1

0

Small-scale

0.458

High

282601

FBX11
F-box only protein 11

1

0

Small-scale

0.458

High

282550

SC24D
Protein transport protein Sec24D

1

3

Small-scale

0.445

High

282551

SC24A
Protein transport protein Sec24A

1

3

Small-scale

0.445

High

282552

SC24B
Protein transport protein Sec24B

1

3

Small-scale

0.445

High

282571

SC24C
Protein transport protein Sec24C

1

3

Small-scale

0.445

High

282574

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

3

Small-scale

0.445

High

282623

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.437

High

282565

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

282603

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

282619

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

282625

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

1

High-throughput

0.407

High

282615

ASIC4
Acid-sensing ion channel 4

2

0

High-throughput

0.324

High

282554

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

282582

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

282599

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

282604

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

282607

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

282639

PCDGH
Protocadherin gamma-B5

1

0

High-throughput

0.279

Low

282570

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.268

Low

282585

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.268

Low

282591

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.268

Low

282595

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.268

Low

282596

ADAL
N6-Methyl-AMP deaminase

1

0

High-throughput

0.268

Low

282608

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.268

Low

282610

LAR4B
La-related protein 4B

1

0

High-throughput

0.268

Low

282630

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.268

Low

282616

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.249

Low

282636

FXL21
Putative F-box/LRR-repeat protein 21

1

0

Small-scale

0.249

Low

282588

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025