HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 471
+	Mm
		1362590 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		NONO_MOUSE (1-471): 4.76e-93: 291: 98.31
+	Mm
		711004 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		PABP1_MOUSE (66-459): 9.73e-67: 227: 14.52
+	Hs
		285383 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		PSPC1_HUMAN (20-470): 4.71e-67: 225: 58.41
+	Mm
		1341538 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		PSPC1_MOUSE (20-470): 1.01e-66: 224: 56.29
+	Mm
		1354142 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		SFPQ_MOUSE (23-471): 5.65e-55: 196: 57.45
+	Hs
		285079 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		SFPQ_HUMAN (45-471): 2.56e-54: 195: 58.73
+	Hs
		285305 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		ELAV1_HUMAN (68-205): 7.41e-47: 166: 27.82
+	Mm
		1000316 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		ELAV1_MOUSE (68-205): 2.06e-46: 165: 28.48
+	Hs
		1144435 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		NONO_HUMAN (1-471): 1.63e-96: 300: 100.00
+	Mm
		1298129 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		RBM4_MOUSE (75-182): 5.45e-09: 59.7: 35.71
+	Hs
		285452 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		RBM4_HUMAN (75-182): 7.68e-09: 59.3: 35.71
+	Hs
		1360438 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		PSPC1_HUMAN (20-470): 4.71e-67: 225: 58.41
+	Hs
		655294 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		SFPQ_HUMAN (45-471): 2.56e-54: 195: 58.73
+	Hs
		550204 WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09		PABP1_HUMAN (66-459): 4.75e-67: 228: 14.52
+	Hs
		1152655 NLE1_HUMAN (296-440): 9.08e-25: 108: 16.45		ELAV1_HUMAN (68-205): 7.41e-47: 166: 27.82
+	Hs
		655135 WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09		SFPQ_HUMAN (45-471): 2.56e-54: 195: 58.73
+	Hs
		1152591 THOC3_HUMAN (148-434): 3.99e-16: 81.3: 19.03		ELAV1_HUMAN (68-205): 7.41e-47: 166: 27.82
+	Hs
		1409857 NLE1_HUMAN (296-440): 9.08e-25: 108: 16.45		RBM4B_HUMAN (75-182): 7.13e-09: 59.3: 35.71
+	Hs
		1416130 NLE1_HUMAN (296-440): 9.08e-25: 108: 16.45		RBM4_HUMAN (75-182): 7.68e-09: 59.3: 35.71
+	Hs
		1314137 SNR40_HUMAN (298-441): 2.31e-21: 96.6: 14.29		RAVR1_HUMAN (76-221): 8.38e-12: 69.4: 24.70