Protein: THOC3
THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)

Gene: THOC3
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q96J01

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0000445 - THO complex part of transcription export complex
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0006397 - mRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1340997

THOC2
THO complex subunit 2

7

18

Small-scale

0.746

High

1117205

THOC5
THO complex subunit 5

6

3

Small-scale

0.733

High

1390956

THOC1
THO complex subunit 1

5

2

Small-scale

0.718

High

1118127

DX39B
Spliceosome RNA helicase DDX39B

4

15

Small-scale

0.689

High

1233209

THOC7
THO complex subunit 7

3

3

High-throughput

0.675

High

610828

TCPA
T-complex protein 1 subunit alpha

3

20

Small-scale

0.667

High

821505

TCPZ
T-complex protein 1 subunit zeta

3

20

Small-scale

0.667

High

882090

TCPG
T-complex protein 1 subunit gamma

3

20

Small-scale

0.667

High

899527

TCPD
T-complex protein 1 subunit delta

3

20

Small-scale

0.667

High

1290112

THOC4
THO complex subunit 4

3

6

Small-scale

0.646

High

1292051

THOC6
THO complex subunit 6

2

16

High-throughput

0.628

High

1365958

APBP2
Amyloid protein-binding protein 2

2

6

High-throughput

0.628

High

876117

TCPE
T-complex protein 1 subunit epsilon

3

20

Small-scale

0.609

High

1007203

TCPB
T-complex protein 1 subunit beta

3

20

Small-scale

0.609

High

242597

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

1066747

NCBP1
Nuclear cap-binding protein subunit 1

2

1

Small-scale

0.584

High

1394572

THOC3
THO complex subunit 3

2

16

Small-scale

0.584

High

273086

CLU
Clustered mitochondria protein homolog

2

4

High-throughput

0.574

High

1363671

TCPW
T-complex protein 1 subunit zeta-2

2

20

High-throughput

0.574

High

396716

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1394575

TCPH
T-complex protein 1 subunit eta

2

20

Small-scale

0.558

High

1198634

NCBP3
Nuclear cap-binding protein subunit 3

2

1

High-throughput

0.552

High

1394576

KLDC3
Kelch domain-containing protein 3

1

5

High-throughput

0.536

High

1394582

BCLF1
Bcl-2-associated transcription factor 1

1

9

High-throughput

0.536

High

951811

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

High-throughput

0.501

High

1006091

DLG4
Disks large homolog 4

1

1

High-throughput

0.494

High

1332984

MLKL
Mixed lineage kinase domain-like protein

1

1

High-throughput

0.494

High

867344

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.489

High

799396

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.481

High

134829

SAP18
Histone deacetylase complex subunit SAP18

1

2

High-throughput

0.479

High

248042

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

279461

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

350110

SNAI1
Zinc finger protein SNAI1

1

5

High-throughput

0.479

High

372853

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

406510

MYCN
N-myc proto-oncogene protein

1

19

High-throughput

0.479

High

414410

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

426317

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

4

Small-scale

0.479

High

428911

RLA0
Large ribosomal subunit protein uL10

1

7

Small-scale

0.479

High

447318

NPM
Nucleophosmin

1

6

Small-scale

0.479

High

462569

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

14

Small-scale

0.479

High

472987

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.479

High

658342

RS3
Small ribosomal subunit protein uS3

1

4

Small-scale

0.479

High

673932

RS12
Small ribosomal subunit protein eS12

1

2

Small-scale

0.479

High

687481

PTBP1
Polypyrimidine tract-binding protein 1

1

11

Small-scale

0.479

High

716937

RL12
Large ribosomal subunit protein uL11

1

3

Small-scale

0.479

High

729405

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

14

Small-scale

0.479

High

794585

RBMX
RNA-binding motif protein, X chromosome

1

9

High-throughput

0.479

High

809783

RS19
Small ribosomal subunit protein eS19

1

2

Small-scale

0.479

High

859395

RL5
Large ribosomal subunit protein uL18

1

4

Small-scale

0.479

High

905034

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

908443

HDGF
Hepatoma-derived growth factor

1

9

High-throughput

0.479

High

909662

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

20

Small-scale

0.479

High

957476

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

966744

1433G
14-3-3 protein gamma

1

17

Small-scale

0.479

High

967521

RS7
Small ribosomal subunit protein eS7

1

2

Small-scale

0.479

High

978660

RL23A
Large ribosomal subunit protein uL23

1

3

Small-scale

0.479

High

980145

H4
Histone H4

1

5

High-throughput

0.479

High

983330

RS28
Small ribosomal subunit protein eS28

1

1

Small-scale

0.479

High

992915

RACK1
Small ribosomal subunit protein RACK1

1

19

Small-scale

0.479

High

994725

YBOX1
Y-box-binding protein 1

1

3

Small-scale

0.479

High

998682

H31
Histone H3.1

1

7

High-throughput

0.479

High

1024768

VIGLN
Vigilin

1

14

High-throughput

0.479

High

1107112

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1114000

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1152591

ELAV1
ELAV-like protein 1

1

3

Small-scale

0.479

High

1280412

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1290653

ZCH18
Zinc finger CCCH domain-containing protein 18

1

17

High-throughput

0.479

High

1334781

SERB1
SERPINE1 mRNA-binding protein 1

1

2

Small-scale

0.479

High

1364208

TOPB1
DNA topoisomerase 2-binding protein 1

1

10

High-throughput

0.479

High

1367023

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

1368862

RBP56
TATA-binding protein-associated factor 2N

1

10

High-throughput

0.479

High

1394574

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1394578

API5
Apoptosis inhibitor 5

1

1

High-throughput

0.479

High

1394579

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

High-throughput

0.479

High

1394580

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1394581

ANLN
Anillin

1

3

High-throughput

0.479

High

1394583

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

992520

RS21
Small ribosomal subunit protein eS21

1

0

Small-scale

0.458

High

1313336

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1119254

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

1209520

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

157734

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.437

High

294181

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

319981

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.437

High

389756

FETUA
Alpha-2-HS-glycoprotein

1

1

Small-scale

0.437

High

390139

ALBU
Albumin

1

1

Small-scale

0.437

High

401309

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.437

High

428208

RLA1
Large ribosomal subunit protein P1

1

1

Small-scale

0.437

High

428477

RLA2
Large ribosomal subunit protein P2

1

2

Small-scale

0.437

High

457982

TRY1
Serine protease 1

1

1

Small-scale

0.437

High

555740

ACTN1
Alpha-actinin-1

1

1

Small-scale

0.437

High

691334

1433T
14-3-3 protein theta

1

17

Small-scale

0.437

High

899175

TCPQ
T-complex protein 1 subunit theta

1

20

Small-scale

0.437

High

970931

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.437

High

1227261

A16L1
Autophagy-related protein 16-1

1

18

High-throughput

0.437

High

1255079

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1358087

NUDC2
NudC domain-containing protein 2

1

15

High-throughput

0.437

High

1394573

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

1394584

UBQL2
Ubiquilin-2

1

2

High-throughput

0.437

High

1203226

ODFP2
Outer dense fiber protein 2

1

12

High-throughput

0.407

High

1337753

KLDC9
Kelch domain-containing protein 9

2

0

High-throughput

0.328

High

1218632

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.279

Low

405527

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.265

Low

616224

PGAM1
Phosphoglycerate mutase 1

1

0

Small-scale

0.249

Low

1135775

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1338319

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1394577

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025