HitPredict

Interactor 1: KS6A5 (O75582)
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Gene: RPS6KA5

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0099175 - regulation of postsynapse organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 191
+	Hs
		908172 KS6A3_HUMAN (366-776): 1.85e-106: 344: 23.47		RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17
+	Hs
		601185 AKT2_HUMAN (365-708): 1.2e-103: 329: 29.36		RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94
+	Hs
		908091 KS6A3_HUMAN (366-776): 1.85e-106: 344: 23.47		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		605811 KAPCA_HUMAN (422-737): 1.77e-99: 314: 27.66		RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17
+	Hs
		605631 KAPCA_HUMAN (422-737): 1.77e-99: 314: 27.66		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		728154 AKT1_HUMAN (375-708): 5.47e-98: 314: 26.14		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		605617 KAPCA_HUMAN (422-737): 1.77e-99: 314: 27.66		CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00
+	Hs
		605623 KAPCA_HUMAN (422-737): 1.77e-99: 314: 27.66		RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48
+	Hs
		658584 KS6B1_HUMAN (393-797): 1.45e-94: 307: 22.92		CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00
+	Hs
		466097 KAPCA_HUMAN (422-737): 1.77e-99: 314: 27.66		RHOC_HUMAN (5-191): 3.38e-76: 228: 52.41
+	Hs
		605730 KAPCA_HUMAN (422-737): 1.77e-99: 314: 27.66		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		601198 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94
+	Hs
		835634 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		835626 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00
+	Hs
		835645 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73
+	Mm
		953804 KPCI_MOUSE (401-676): 1.53e-25: 114: 27.84		CDC42_MOUSE (1-191): 9.95e-80: 237: 100.00
+	Hs
		835627 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48
+	Hs
		580909 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75
+	Hs
		466137 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		RHOC_HUMAN (5-191): 3.38e-76: 228: 52.41
+	Hs
		835625 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32