HitPredict

Interactor 1: UBA1 (O94609)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45) (Poly(A)+ RNA transport protein 3)
Gene: ptr3

Interactor 2: UBC4 (P46595)
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)
Gene: UBC4

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.862

Property	Details
Experiments	23416107, 28162934, 28572513
Identification Methods	enzymatic study, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1012 Sp			1 147
+	Hs
		607190 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UB2D4_HUMAN (1-147): 2.47e-83: 242: 83.67
+	Hs
		607026 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UB2D1_HUMAN (1-147): 1.88e-82: 240: 79.59
+	Hs
		607050 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UB2D2_HUMAN (1-147): 3.47e-82: 239: 84.35
+	Hs
		607039 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UB2D3_HUMAN (1-147): 3.92e-81: 237: 84.35
+	Hs
		607136 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UB2E2_HUMAN (4-146): 1.79e-74: 222: 66.43
+	Hs
		607129 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UB2E3_HUMAN (4-146): 7.18e-74: 221: 66.43
+	Hs
		607028 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UB2E1_HUMAN (4-146): 1.92e-72: 216: 66.43
+	Hs
		607023 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UBE2A_HUMAN (2-144): 9.92e-71: 211: 39.16
+	Hs
		607054 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UBE2B_HUMAN (2-144): 4.55e-70: 209: 39.16
+	Hs
		607042 UBA1_HUMAN (1-1012): 0: 1212: 52.97		UBE2N_HUMAN (4-147): 1.08e-68: 206: 47.22
+	Sc
		549788 UBA1_YEAST (2-1012): 0: 1122: 58.44		UBC4_YEAST (3-147): 1.31e-79: 233: 83.45
+	Sp
		251976 UBA1_SCHPO (1-1012): 0: 1193: 100.00		UBC1_SCHPO (4-146): 2.19e-44: 146: 45.83
+	Sp
		293851 UBA1_SCHPO (1-1012): 0: 1193: 100.00		UBC14_SCHPO (6-146): 6.86e-43: 140: 47.18
+	Sp
		142467 UBA1_SCHPO (1-1012): 0: 1193: 100.00		UBC13_SCHPO (1-147): 1.58e-42: 139: 47.97
+	Dm
		715098 Q8T0L3_DROME (2-1012): 0: 1100: 50.74		UBE2N_DROME (4-147): 6.7e-72: 214: 47.22
+	Hs
		48104 UBA6_HUMAN (2-1012): 0: 1038: 39.69		UB2D1_HUMAN (1-147): 1.88e-82: 240: 79.59
+	Hs
		48107 UBA6_HUMAN (2-1012): 0: 1038: 39.69		UB2D2_HUMAN (1-147): 3.47e-82: 239: 84.35
+	Hs
		48106 UBA6_HUMAN (2-1012): 0: 1038: 39.69		UB2D3_HUMAN (1-147): 3.92e-81: 237: 84.35
+	Hs
		782203 UBA7_HUMAN (7-1012): 0: 981: 37.85		UB2E1_HUMAN (4-146): 1.92e-72: 216: 66.43
+	Hs
		1282360 SAE2_HUMAN (25-385): 5.42e-77: 267: 13.29		UB2E3_HUMAN (4-146): 7.18e-74: 221: 66.43