HitPredict

Interactor 1: PIAS1 (O75925)
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)
Gene: PIAS1

Interactor 2: NFIX (Q14938)
Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein)
Gene: NFIX

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	39617063
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Hs			1 502
+	Hs
		297592 PIAS1_HUMAN (1-651): 0: 874: 100.00		NFIA_HUMAN (1-502): 1.45e-118: 359: 66.47
+	Hs
		297409 PIAS1_HUMAN (1-651): 0: 874: 100.00		NFIC_HUMAN (3-502): 4.99e-114: 348: 53.43
+	Hs
		1133769 PIAS3_HUMAN (1-651): 0: 740: 56.88		NFIX_HUMAN (1-502): 5.28e-159: 462: 100.00
+	Hs
		142763 PIAS1_HUMAN (1-651): 0: 874: 100.00		NFIB_HUMAN (1-419): 3.83e-101: 311: 58.69
+	Hs
		297812 PIAS2_HUMAN (1-566): 0: 633: 58.97		NFIX_HUMAN (1-502): 5.28e-159: 462: 100.00
+	Hs
		1133531 PIAS4_HUMAN (2-423): 0: 550: 51.42		NFIX_HUMAN (1-502): 5.28e-159: 462: 100.00
+	Hs
		297801 PIAS2_HUMAN (1-566): 0: 633: 58.97		NFIA_HUMAN (1-502): 1.45e-118: 359: 66.47
+	Hs
		297737 PIAS2_HUMAN (1-566): 0: 633: 58.97		NFIC_HUMAN (3-502): 4.99e-114: 348: 53.43
+	Hs
		142764 PIAS2_HUMAN (1-566): 0: 633: 58.97		NFIB_HUMAN (1-419): 3.83e-101: 311: 58.69
+	Hs
		1087866 PIAS4_HUMAN (2-423): 0: 550: 51.42		NFIA_HUMAN (1-502): 1.45e-118: 359: 66.47
+	Hs
		474122 PIAS4_HUMAN (2-423): 0: 550: 51.42		NFIC_HUMAN (3-502): 4.99e-114: 348: 53.43
+	Hs
		143116 PIAS4_HUMAN (2-423): 0: 550: 51.42		NFIB_HUMAN (1-419): 3.83e-101: 311: 58.69
+	Hs
		1133541 ZMIZ2_HUMAN (64-423): 3.95e-88: 296: 23.04		NFIX_HUMAN (1-502): 5.28e-159: 462: 100.00
+	Hs
		1133732 ZMIZ1_HUMAN (65-441): 7.61e-76: 264: 20.21		NFIX_HUMAN (1-502): 5.28e-159: 462: 100.00
+	Hs
		1087876 ZMIZ2_HUMAN (64-423): 3.95e-88: 296: 23.04		NFIA_HUMAN (1-502): 1.45e-118: 359: 66.47
+	Hs
		474134 ZMIZ2_HUMAN (64-423): 3.95e-88: 296: 23.04		NFIC_HUMAN (3-502): 4.99e-114: 348: 53.43
+	Hs
		1088095 ZMIZ1_HUMAN (65-441): 7.61e-76: 264: 20.21		NFIA_HUMAN (1-502): 1.45e-118: 359: 66.47
+	Hs
		474367 ZMIZ1_HUMAN (65-441): 7.61e-76: 264: 20.21		NFIC_HUMAN (3-502): 4.99e-114: 348: 53.43
+	Hs
		143125 ZMIZ2_HUMAN (64-423): 3.95e-88: 296: 23.04		NFIB_HUMAN (1-419): 3.83e-101: 311: 58.69
+	Hs
		143323 ZMIZ1_HUMAN (65-441): 7.61e-76: 264: 20.21		NFIB_HUMAN (1-419): 3.83e-101: 311: 58.69