HitPredict

Interactor 1: KLH18 (O94889)
Kelch-like protein 18
Gene: KLHL18

Interactor 2: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.609

Property	Details
Experiments	28514442, 28581483, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 183
+	Hs
		896269 KLH20_HUMAN (15-570): 2.14e-176: 513: 42.55		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		896119 KLH26_HUMAN (14-572): 2.25e-161: 475: 28.87		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		896288 NS1BP_HUMAN (197-459): 2.34e-51: 188: 29.17		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		307160 KLHL2_HUMAN (259-430): 6.05e-37: 146: 42.53		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		849329 KEAP1_HUMAN (417-572): 1.15e-31: 131: 30.63		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		895941 KLHL3_HUMAN (426-571): 2.1e-33: 136: 34.93		UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51
+	Hs
		896117 KLH12_HUMAN (414-572): 3.15e-33: 135: 27.61		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		849470 KLHL9_HUMAN (431-573): 9.96e-28: 119: 24.67		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		849471 KLH13_HUMAN (431-573): 1.06e-27: 119: 25.33		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		828997 KEAP1_HUMAN (417-572): 1.15e-31: 131: 30.63		UBE2A_HUMAN (26-172): 2.67e-69: 208: 28.19
+	Hs
		896241 KLHL9_HUMAN (431-573): 9.96e-28: 119: 24.67		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		896243 KLH13_HUMAN (431-573): 1.06e-27: 119: 25.33		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		896130 KLH24_HUMAN (282-384): 2.26e-10: 65.2: 26.92		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		135913 KLHL2_HUMAN (259-430): 6.05e-37: 146: 42.53		UBE2C_HUMAN (10-155): 3e-22: 90.1: 34.46
+	Hs
		307184 KLHL2_HUMAN (259-430): 6.05e-37: 146: 42.53		Q5TZN3_HUMAN (10-155): 3e-22: 90.1: 34.46