Protein: PIM1
Serine/threonine-protein kinase pim-1 (EC 2.7.11.1)

Gene: PIM1
Organism: Homo sapiens
Interactions: 123
UniProt ID: P11309

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

540985

MARK3
MAP/microtubule affinity-regulating kinase 3

5

16

Small-scale

0.933

High

362668

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

540979

PIM1
Serine/threonine-protein kinase pim-1

2

18

Small-scale

0.755

High

461077

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.754

High

540987

MPIP1
M-phase inducer phosphatase 1

1

4

Small-scale

0.724

High

467227

MDR1
ATP-dependent translocase ABCB1

1

0

Small-scale

0.708

High

541067

ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2

1

1

Small-scale

0.700

High

540991

CDN1A
Cyclin-dependent kinase inhibitor 1

1

9

Small-scale

0.692

High

541006

DAPK1
Death-associated protein kinase 1

1

19

High-throughput

0.692

High

540981

KPCA
Protein kinase C alpha type

1

18

Small-scale

0.691

High

541040

DCP1B
mRNA-decapping enzyme 1B

4

2

High-throughput

0.691

High

541061

DCP1A
mRNA-decapping enzyme 1A

4

2

High-throughput

0.691

High

541050

EDC3
Enhancer of mRNA-decapping protein 3

5

0

High-throughput

0.686

High

540984

DDX6
Probable ATP-dependent RNA helicase DDX6

3

4

High-throughput

0.667

High

541014

MDM2
E3 ubiquitin-protein ligase Mdm2

2

4

Small-scale

0.650

High

541005

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

18

Small-scale

0.646

High

541043

DCAF4
DDB1- and CUL4-associated factor 4

3

0

High-throughput

0.638

High

541066

SNX6
Sorting nexin-6

2

6

Small-scale

0.631

High

371025

MYC
Myc proto-oncogene protein

2

10

Small-scale

0.624

High

468003

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

540996

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

9

Small-scale

0.618

High

541020

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.618

High

541017

CBX3
Chromobox protein homolog 3

1

3

Small-scale

0.586

High

541018

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.578

High

299511

TRIO
Triple functional domain protein

1

11

High-throughput

0.575

High

540982

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

17

Small-scale

0.575

High

540997

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

18

High-throughput

0.575

High

541022

RAB32
Ras-related protein Rab-32

1

6

High-throughput

0.575

High

541025

RHEB
GTP-binding protein Rheb

1

5

High-throughput

0.575

High

541031

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

1

High-throughput

0.575

High

541037

PIM3
Serine/threonine-protein kinase pim-3

1

18

High-throughput

0.575

High

541055

KPCD2
Serine/threonine-protein kinase D2

1

17

High-throughput

0.575

High

541058

WNK1
Serine/threonine-protein kinase WNK1

1

17

High-throughput

0.575

High

541059

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

19

High-throughput

0.575

High

464239

FUMH
Fumarate hydratase, mitochondrial

1

2

High-throughput

0.573

High

541003

FXR2
RNA-binding protein FXR2

1

2

High-throughput

0.573

High

541051

HEXI2
Protein HEXIM2

1

2

High-throughput

0.573

High

541069

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

2

High-throughput

0.573

High

340812

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

8

Small-scale

0.561

High

541016

CDC20
Cell division cycle protein 20 homolog

1

9

Small-scale

0.561

High

541023

NUMA1
Nuclear mitotic apparatus protein 1

1

10

Small-scale

0.561

High

541065

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.561

High

541035

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

Small-scale

0.552

High

503546

TFPT
TCF3 fusion partner

1

0

High-throughput

0.549

High

541042

BANP
Protein BANP

1

0

High-throughput

0.549

High

540988

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

High-throughput

0.541

High

540992

RS19
Small ribosomal subunit protein eS19

1

0

Small-scale

0.538

High

423731

APOD
Apolipoprotein D

1

1

High-throughput

0.536

High

479103

ENOG
Gamma-enolase

1

4

High-throughput

0.536

High

540986

SPB3
Serpin B3

1

3

High-throughput

0.536

High

540998

UTRN
Utrophin

1

13

High-throughput

0.536

High

541056

FOXP3
Forkhead box protein P3

1

2

Small-scale

0.536

High

541072

S4A7
Sodium bicarbonate cotransporter 3

1

4

High-throughput

0.536

High

541011

ATL3
ADAMTS-like protein 3

1

3

High-throughput

0.514

High

541019

TARB1
tRNA

1

0

High-throughput

0.513

High

541033

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

541049

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

421393

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

541009

UBC9
SUMO-conjugating enzyme UBC9

1

4

Small-scale

0.501

High

541010

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

15

Small-scale

0.501

High

541013

H33
Histone H3.3

1

6

Small-scale

0.501

High

541034

H32
Histone H3.2

1

6

Small-scale

0.501

High

541046

BAD
Bcl2-associated agonist of cell death

1

4

Small-scale

0.501

High

541063

SENP1
Sentrin-specific protease 1

1

1

Small-scale

0.501

High

541070

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

261590

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

541015

HEN1
Helix-loop-helix protein 1

1

3

High-throughput

0.481

High

219686

FOXO3
Forkhead box protein O3

1

9

Small-scale

0.479

High

297424

PIAS1
E3 SUMO-protein ligase PIAS1

1

4

Small-scale

0.479

High

540793

ERG
Transcriptional regulator ERG

1

2

Small-scale

0.479

High

540989

HSP74
Heat shock 70 kDa protein 4

1

13

Small-scale

0.479

High

541000

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

Small-scale

0.479

High

541008

MAX
Protein max

1

8

Small-scale

0.479

High

541012

CBX1
Chromobox protein homolog 1

1

3

Small-scale

0.479

High

541021

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

Small-scale

0.479

High

541024

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

3

Small-scale

0.479

High

541052

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

12

Small-scale

0.479

High

541073

PIAS3
E3 SUMO-protein ligase PIAS3

1

4

Small-scale

0.479

High

541028

Q5T203
Nescient helix loop helix 1

1

3

High-throughput

0.470

High

229406

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

2

High-throughput

0.445

High

442558

RB
Retinoblastoma-associated protein

1

1

High-throughput

0.445

High

540980

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.445

High

540983

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

2

High-throughput

0.445

High

540990

COIL
Coilin

1

2

High-throughput

0.445

High

540993

MLH1
DNA mismatch repair protein Mlh1

1

2

High-throughput

0.445

High

540994

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.445

High

541001

TSC2
Tuberin

1

2

High-throughput

0.445

High

541002

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

2

High-throughput

0.445

High

541004

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

1

3

High-throughput

0.445

High

541026

ERC6L
DNA excision repair protein ERCC-6-like

1

3

High-throughput

0.445

High

541030

TENS3
Tensin-3

1

3

High-throughput

0.445

High

541047

AKTS1
Proline-rich AKT1 substrate 1

1

5

Small-scale

0.445

High

541054

TB10A
TBC1 domain family member 10A

1

2

High-throughput

0.445

High

541060

AT131
Endoplasmic reticulum transmembrane helix translocase

1

3

High-throughput

0.445

High

541062

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

1

High-throughput

0.445

High

541068

TTF2
Transcription termination factor 2

1

4

High-throughput

0.445

High

541071

STA13
StAR-related lipid transfer protein 13

1

10

High-throughput

0.445

High

75651

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

249955

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.426

High

301843

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.426

High

333548

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

High-throughput

0.426

High

341234

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

1

0

High-throughput

0.426

High

405383

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.426

High

541027

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.426

High

541032

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

541038

TPPC5
Trafficking protein particle complex subunit 5

1

0

High-throughput

0.426

High

541039

SYT12
Synaptotagmin-12

1

0

High-throughput

0.426

High

541044

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.426

High

541048

INT12
Integrator complex subunit 12

1

0

High-throughput

0.426

High

69471

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

517204

AMY1B
Alpha-amylase 1B

1

1

High-throughput

0.407

High

540995

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.407

High

541036

ATL2
ADAMTS-like protein 2

1

3

High-throughput

0.407

High

541045

AP3S1
AP-3 complex subunit sigma-1

1

2

High-throughput

0.407

High

541057

S2532
Solute carrier family 25 member 32

1

4

High-throughput

0.407

High

541041

BEND7
BEN domain-containing protein 7

1

0

High-throughput

0.299

High

540999

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

541029

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

248554

FADS1
Acyl-CoA

1

0

High-throughput

0.232

Low

541007

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.232

Low

541053

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.232

Low

541064

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025