HitPredict

Interactor 1: CDK14 (O94921)
Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)
Gene: CDK14

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.649

Property	Details
Experiments	36931259, 16775625
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 246
+	Hs
		300632 CDK14_HUMAN (1-469): 8.61e-164: 472: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		300633 CDK14_HUMAN (1-469): 8.61e-164: 472: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		300626 CDK14_HUMAN (1-469): 8.61e-164: 472: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		625306 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		625334 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		909447 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683268 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		909472 CDK18_HUMAN (3-466): 7.76e-132: 391: 45.69		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683288 CDK18_HUMAN (3-466): 7.76e-132: 391: 45.69		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		300631 CDK14_HUMAN (1-469): 8.61e-164: 472: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		300636 CDK14_HUMAN (1-469): 8.61e-164: 472: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		625130 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		646799 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		646826 CDK18_HUMAN (3-466): 7.76e-132: 391: 45.69		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		625296 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		625383 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		960082 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		904478 CDK18_HUMAN (3-466): 7.76e-132: 391: 45.69		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		683964 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		683985 CDK18_HUMAN (3-466): 7.76e-132: 391: 45.69		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62