HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031410 - cytoplasmic vesicle GO:0098794 - postsynapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 939 Hs			1 2527
+	Hs
		72401 B3KXW5_HUMAN (1-811): 0: 614: 25.12		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1014027 AP1B1_HUMAN (36-934): 0: 606: 17.35		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		3574 A0A140VJE8_HUMAN (36-933): 0: 599: 15.57		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		276370 AP1G2_HUMAN (13-816): 0: 554: 25.83		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		150222 AP3D1_HUMAN (11-478): 3.33e-33: 140: 23.51		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		302135 AP2A2_HUMAN (1-939): 0: 884: 100.00		M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38
+	Hs
		321525 AP2A1_HUMAN (1-939): 0: 832: 78.47		M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38