HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	30894683, 23667531
Identification Methods	affinity chromatography technology, unspecified method, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 317
+	Hs
		304358 UBR5_HUMAN (1-2799): 0: 3949: 100.00		TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75
+	Hs
		304139 UBR5_HUMAN (1-2799): 0: 3949: 100.00		SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68
+	Hs
		818354 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Hs
		125241 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Mm
		818769 WWP2_MOUSE (2430-2797): 2.32e-129: 432: 21.47		SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67
+	Hs
		1342342 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32
+	Hs
		996907 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68
+	Hs
		125410 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68
+	Hs
		1264304 NED4L_HUMAN (2187-2796): 1.96e-123: 418: 18.20		BBX_HUMAN (20-260): 9.07e-30: 121: 19.75
+	Hs
		1192175 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		CIC_HUMAN (3-272): 8.9e-33: 130: 22.26