HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: EREP1 (Q15884)
Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)
Gene: ENTREP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.50	0.417

Property	Details
Experiments	34927784
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 450
+	Hs
		1079795 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079771 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		125488 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079783 WWP1_HUMAN (2180-2797): 2.84e-126: 425: 18.43		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079773 NED4L_HUMAN (2187-2796): 1.96e-123: 418: 18.20		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		808136 NEDD4_HUMAN (2446-2796): 8.62e-120: 416: 23.98		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079753 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		946405 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		946449 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		946429 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		946437 WWP1_HUMAN (2180-2797): 2.84e-126: 425: 18.43		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		946430 NED4L_HUMAN (2187-2796): 1.96e-123: 418: 18.20		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		808086 NEDD4_HUMAN (2446-2796): 8.62e-120: 416: 23.98		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		125597 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53
+	Hs
		1259694 WWP1_HUMAN (2180-2797): 2.84e-126: 425: 18.43		Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53