Protein: ERD22
ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)

Gene: ERD22, KDELR2
Organism: Homo sapiens
Interactions: 107
UniProt ID: P33947

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005046 - KDEL sequence binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005801 - cis-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

410659

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

3

High-throughput

0.585

High

516646

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

1

High-throughput

0.575

High

49731

TMM72
Transmembrane protein 72

1

1

High-throughput

0.536

High

538531

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.536

High

563300

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

634745

GRAH
Granzyme H

1

2

High-throughput

0.536

High

652282

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

755487

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.536

High

755505

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

5

High-throughput

0.536

High

755516

GINM1
Glycoprotein integral membrane protein 1

1

1

High-throughput

0.536

High

755518

TSP50
Probable threonine protease PRSS50

1

1

High-throughput

0.536

High

755479

SERC3
Serine incorporator 3

1

1

High-throughput

0.515

High

260840

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

418604

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

High-throughput

0.513

High

421590

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.513

High

519594

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.513

High

755474

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

755475

PLP2
Proteolipid protein 2

1

0

High-throughput

0.513

High

755477

SBP1
Methanethiol oxidase

1

0

High-throughput

0.513

High

755493

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.513

High

755498

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

755500

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

755512

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.513

High

755520

NEUR2
Sialidase-2

1

0

High-throughput

0.513

High

465427

IGF1R
Insulin-like growth factor 1 receptor

1

2

High-throughput

0.501

High

472001

MET
Hepatocyte growth factor receptor

1

2

High-throughput

0.501

High

593289

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.501

High

648438

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.501

High

728057

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

High-throughput

0.501

High

755461

ERD22
ER lumen protein-retaining receptor 2

1

4

High-throughput

0.501

High

755465

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

1

High-throughput

0.501

High

165911

FFAR1
Free fatty acid receptor 1

1

10

High-throughput

0.489

High

277573

H2AY
Core histone macro-H2A.1

1

1

High-throughput

0.489

High

669183

EDNRA
Endothelin-1 receptor

1

3

High-throughput

0.489

High

732956

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

4

High-throughput

0.489

High

755467

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.489

High

755476

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.489

High

755501

LRC15
Leucine-rich repeat-containing protein 15

1

1

High-throughput

0.489

High

755508

OPALI
Opalin

1

2

High-throughput

0.489

High

755513

KLK15
Kallikrein-15

1

2

High-throughput

0.489

High

755522

EPN1
Epsin-1

1

2

High-throughput

0.489

High

755463

MERL
Merlin

1

0

High-throughput

0.480

High

755482

BECN1
Beclin-1

1

0

High-throughput

0.480

High

755483

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.480

High

225360

ERD23
ER lumen protein-retaining receptor 3

1

4

High-throughput

0.479

High

395584

ESR1
Estrogen receptor

1

3

High-throughput

0.479

High

664947

ERD21
ER lumen protein-retaining receptor 1

1

4

High-throughput

0.479

High

755462

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

176942

CE290
Centrosomal protein of 290 kDa

1

0

High-throughput

0.458

High

184271

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

755494

CNTRL
Centriolin

1

0

High-throughput

0.458

High

549072

CDK4
Cyclin-dependent kinase 4

1

1

High-throughput

0.457

High

710090

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.457

High

755464

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

1

High-throughput

0.457

High

755472

CDK6
Cyclin-dependent kinase 6

1

1

High-throughput

0.457

High

755514

LATS2
Serine/threonine-protein kinase LATS2

1

3

High-throughput

0.457

High

248842

GSDME
Gasdermin-E

1

1

High-throughput

0.445

High

343229

ERR2
Steroid hormone receptor ERR2

1

3

High-throughput

0.437

High

755468

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.437

High

755470

KS6A3
Ribosomal protein S6 kinase alpha-3

1

2

High-throughput

0.437

High

755509

FMNL2
Formin-like protein 2

1

1

High-throughput

0.437

High

755466

GPR12
G-protein coupled receptor 12

1

6

High-throughput

0.407

High

755503

LPAR1
Lysophosphatidic acid receptor 1

1

7

High-throughput

0.407

High

755517

PARP2
Poly [ADP-ribose] polymerase 2

1

1

Small-scale

0.407

High

139183

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

220149

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

302762

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.279

Low

326665

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

502252

H2A1
Histone H2A type 1

1

0

High-throughput

0.279

Low

582551

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.279

Low

595324

H15
Histone H1.5

1

0

High-throughput

0.279

Low

692659

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

749308

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

754557

S10A3
Protein S100-A3

1

0

High-throughput

0.279

Low

755469

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

0

High-throughput

0.279

Low

755480

PKP1
Plakophilin-1

1

0

High-throughput

0.279

Low

755481

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.279

Low

755484

EIPR1
EARP and GARP complex-interacting protein 1

1

0

High-throughput

0.279

Low

755485

CAHM4
Calcium homeostasis modulator protein 4

1

0

High-throughput

0.279

Low

755488

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

755489

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

755490

MZT2B
Mitotic-spindle organizing protein 2B

1

0

High-throughput

0.279

Low

755495

LYG2
Lysozyme g-like protein 2

1

0

High-throughput

0.279

Low

755496

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

755502

PPM1E
Protein phosphatase 1E

1

0

High-throughput

0.279

Low

755511

LST8
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.279

Low

755519

PADI3
Protein-arginine deiminase type-3

1

0

High-throughput

0.279

Low

755521

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.279

Low

371301

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.261

Low

591232

CD44
CD44 antigen

1

0

High-throughput

0.261

Low

718765

CCND2
G1/S-specific cyclin-D2

1

0

High-throughput

0.261

Low

755478

GRM1
Metabotropic glutamate receptor 1

1

0

High-throughput

0.261

Low

755504

KAT2A
Histone acetyltransferase KAT2A

1

0

High-throughput

0.261

Low

755510

TTYH2
Protein tweety homolog 2

1

0

High-throughput

0.261

Low

755515

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.261

Low

227399

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

451338

NFM
Neurofilament medium polypeptide

1

0

High-throughput

0.249

Low

755473

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.249

Low

755486

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

755491

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.249

Low

755492

BCOR
BCL-6 corepressor

1

0

High-throughput

0.249

Low

755497

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.249

Low

755499

POC5
Centrosomal protein POC5

1

0

High-throughput

0.249

Low

755506

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

755507

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

755471

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025