Protein: ERD2
ER lumen protein-retaining receptor (Endoplasmic reticulum retention defective protein 2) (HDEL receptor)

Gene: ERD2
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: P18414

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005801 - cis-Golgi network
GO:0006621 - protein retention in ER lumen
GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416682

CAN1
Arginine permease CAN1

1

2

High-throughput

0.541

High

613854

TAT2
Tryptophan permease

1

2

High-throughput

0.541

High

613862

SPC1
Signal peptidase complex subunit 1

1

1

High-throughput

0.541

High

592755

ERD1
Protein ERD1

1

0

High-throughput

0.518

High

613864

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.518

High

613867

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.518

High

564701

ATC1
Calcium-transporting ATPase 1

1

5

High-throughput

0.479

High

613846

EMP24
Endosomal protein P24B

1

2

High-throughput

0.479

High

613855

ERP2
Protein ERP2

1

3

High-throughput

0.479

High

613856

ERV46
ER-derived vesicles protein ERV46

1

1

High-throughput

0.479

High

613866

YIP1
Protein transport protein YIP1

1

1

High-throughput

0.479

High

613868

ERV29
ER-derived vesicles protein ERV29

1

2

High-throughput

0.479

High

613871

TMEDA
Endoplasmic reticulum vesicle protein 25

1

3

High-throughput

0.479

High

613875

ERV41
ER-derived vesicles protein ERV41

1

1

High-throughput

0.479

High

613876

ERP1
Protein ERP1

1

3

High-throughput

0.479

High

613879

ERP4
Protein ERP4

1

4

High-throughput

0.479

High

613836

SEC22
Protein transport protein SEC22

1

0

High-throughput

0.458

High

613839

BOS1
Protein transport protein BOS1

1

0

High-throughput

0.458

High

613840

RER1
Protein RER1

1

0

High-throughput

0.458

High

613853

SVP26
Protein SVP26

1

0

High-throughput

0.458

High

613869

ZRG17
Protein ZRG17

1

0

High-throughput

0.458

High

613870

YIF1
Protein transport protein YIF1

1

0

High-throughput

0.458

High

613878

ERV2
FAD-linked sulfhydryl oxidase ERV2

1

0

High-throughput

0.458

High

613857

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.426

High

613874

DOP1
Protein DOP1

1

0

High-throughput

0.426

High

381855

H4
Histone H4

1

1

High-throughput

0.407

High

543748

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

613837

MPCP
Mitochondrial phosphate carrier protein

1

1

High-throughput

0.407

High

613844

IMB3
Importin subunit beta-3

1

3

High-throughput

0.407

High

613848

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.407

High

613849

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.407

High

613851

IMB2
Importin subunit beta-2

1

2

High-throughput

0.407

High

613858

IMB4
Importin subunit beta-4

1

2

High-throughput

0.407

High

613859

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.407

High

613860

BNI1
Protein BNI1

1

2

High-throughput

0.407

High

613863

NMD5
Nonsense-mediated mRNA decay protein 5

1

1

High-throughput

0.407

High

613865

MSN5
Protein MSN5

1

2

High-throughput

0.407

High

613880

MTR10
mRNA transport regulator MTR10

1

1

High-throughput

0.407

High

613872

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

0

High-throughput

0.282

High

613877

TPO3
Polyamine transporter 3

1

0

High-throughput

0.282

High

613850

KTR3
Probable mannosyltransferase KTR3

1

0

High-throughput

0.249

Low

359142

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.232

Low

386556

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

394210

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

427129

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

432482

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.232

Low

450517

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.232

Low

486018

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

525865

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.232

Low

531593

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.232

Low

591992

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

598803

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

High-throughput

0.232

Low

613834

METK2
S-adenosylmethionine synthase 2

1

0

High-throughput

0.232

Low

613835

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

613838

RNA14
mRNA 3'-end-processing protein RNA14

1

0

High-throughput

0.232

Low

613841

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.232

Low

613842

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

613843

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

613845

BRR2
Pre-mRNA-splicing helicase BRR2

1

0

High-throughput

0.232

Low

613847

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low

613852

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.232

Low

613861

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

613873

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025