HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: PHC1 (P78364)
Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)
Gene: PHC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	28514442, 27705803, 24981860, 33961781, 22325352
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016604 - nuclear body GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1004
+	Hs
		69543 B0QXZ6_HUMAN (1-393): 3.76e-108: 325: 95.42		PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00
+	Hs
		943094 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00
+	Hs
		316204 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		SCML2_HUMAN (590-1003): 5.22e-31: 132: 16.14
+	Hs
		316124 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		SCMH1_HUMAN (572-1003): 4.16e-28: 123: 15.94
+	Hs
		327838 CBX7_HUMAN (1-207): 2.43e-45: 159: 33.33		PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00
+	Hs
		316200 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		SCML1_HUMAN (863-1003): 2.3e-15: 80.5: 27.10
+	Hs
		316103 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		PHC3_HUMAN (180-907): 1.62e-09: 64.2: 7.91
+	Hs
		316088 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		PHC2_HUMAN (22-663): 5.23e-09: 62.3: 11.37
+	Hs
		1335794 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		SCML2_HUMAN (590-1003): 5.22e-31: 132: 16.14
+	Hs
		1292155 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		SCMH1_HUMAN (572-1003): 4.16e-28: 123: 15.94
+	Dm
		639970 PC_DROME (10-393): 7.49e-58: 196: 21.04		Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97
+	Dm
		639953 PC_DROME (10-393): 7.49e-58: 196: 21.04		PHP_DROME (36-1003): 2.95e-29: 128: 15.26
+	Hs
		1335791 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		SCML1_HUMAN (863-1003): 2.3e-15: 80.5: 27.10
+	Dr
		1193375 Q804D1_DANRE (1-385): 1.19e-77: 250: 24.21		PHC2_DANRE (4-513): 6.06e-10: 65.4: 21.73
+	Hs
		1242737 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		PHC3_HUMAN (180-907): 1.62e-09: 64.2: 7.91
+	Hs
		1220894 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		PHC2_HUMAN (22-663): 5.23e-09: 62.3: 11.37
+	Dm
		639977 PC_DROME (10-393): 7.49e-58: 196: 21.04		SCM_DROME (918-1001): 3.2e-16: 85.9: 41.18
+	Dm
		639978 PC_DROME (10-393): 7.49e-58: 196: 21.04		SMBT_DROME (921-1002): 9.57e-13: 74.7: 31.71
+	Hs
		327855 CBX7_HUMAN (1-207): 2.43e-45: 159: 33.33		PHC3_HUMAN (180-907): 1.62e-09: 64.2: 7.91
+	Hs
		327853 CBX7_HUMAN (1-207): 2.43e-45: 159: 33.33		PHC2_HUMAN (22-663): 5.23e-09: 62.3: 11.37