HitPredict

Interactor 1: DIRA3 (O95661)
GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI)
Gene: DIRAS3

Interactor 2: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 229 Hs			1 1239
+	Hs
		324774 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		M4K4_HUMAN (1-1239): 0: 1227: 100.00
+	Hs
		324909 RAP2C_HUMAN (35-202): 2.03e-23: 94.4: 36.05		M4K4_HUMAN (1-1239): 0: 1227: 100.00
+	Xl
		1150218 Q7ZX67_XENLA (35-202): 6.88e-25: 98.2: 36.05		Q6DDZ8_XENLA (1-1239): 0: 1097: 59.58
+	Hs
		318068 DIRA3_HUMAN (1-229): 8.18e-88: 260: 100.00		MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23
+	Hs
		318173 DIRA3_HUMAN (1-229): 8.18e-88: 260: 100.00		MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10
+	Hs
		148636 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		647864 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23
+	Hs
		149274 RAB1B_HUMAN (32-227): 2.55e-79: 238: 23.76		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		148551 RAB13_HUMAN (34-228): 1.01e-75: 228: 21.39		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		148600 RAB10_HUMAN (29-227): 1.76e-75: 228: 19.21		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		914159 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10
+	Hs
		895479 RAB10_HUMAN (29-227): 1.76e-75: 228: 19.21		AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85
+	Hs
		318261 DIRA3_HUMAN (1-229): 8.18e-88: 260: 100.00		M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52
+	Hs
		254466 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02
+	Hs
		914488 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52
+	Hs
		914500 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		STK24_HUMAN (20-398): 2.05e-110: 355: 36.65
+	Hs
		681973 RHES_HUMAN (38-202): 6.58e-23: 95.1: 31.03		AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82
+	Dm
		442965 RAP1_DROME (35-196): 1.69e-28: 107: 37.42		HIPPO_DROME (14-316): 8.94e-108: 356: 40.79