HitPredict

Interactor 1: BAG3 (O95817)
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
Gene: BAG3

Interactor 2: HSP76 (P17066)
Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6)
Gene: HSPA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	33957083
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BAG~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0034605 - cellular response to heat
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 575 Hs			1 643
+	Hs
		324435 BAG3_HUMAN (1-575): 0: 809: 100.00		Q53FC7_HUMAN (1-643): 0: 965: 99.22
+	Hs
		324256 BAG3_HUMAN (1-575): 0: 809: 100.00		HS71L_HUMAN (1-643): 0: 960: 79.32
+	Hs
		324195 BAG3_HUMAN (1-575): 0: 809: 100.00		HSP7C_HUMAN (4-615): 0: 940: 79.25
+	Hs
		324190 BAG3_HUMAN (1-575): 0: 809: 100.00		HS71A_HUMAN (5-643): 0: 934: 82.16
+	Hs
		324298 BAG3_HUMAN (1-575): 0: 809: 100.00		HSP72_HUMAN (3-643): 0: 925: 77.45
+	Mm
		926166 BAG3_MOUSE (1-575): 0: 762: 83.31		HSP7C_MOUSE (4-615): 0: 939: 79.25
+	Mm
		571868 BAG3_MOUSE (1-575): 0: 762: 83.31		HS71B_MOUSE (5-643): 0: 938: 80.63
+	Hs
		314001 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		HSP76_HUMAN (1-643): 0: 970: 100.00
+	Hs
		314060 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		Q53FC7_HUMAN (1-643): 0: 965: 99.22
+	Hs
		314010 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		HS71L_HUMAN (1-643): 0: 960: 79.32
+	Mm
		571864 BAG4_MOUSE (381-499): 1.39e-37: 146: 43.70		HS71B_MOUSE (5-643): 0: 938: 80.63
+	Dm
		65607 A8JNS4_DROME (398-498): 1.33e-26: 116: 32.11		HSP72_DROME (7-643): 0: 965: 71.14
+	Hs
		313996 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		HSP7C_HUMAN (4-615): 0: 940: 79.25
+	Hs
		314025 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		HSP72_HUMAN (3-643): 0: 925: 77.45
+	Hs
		564206 BAG5_HUMAN (418-498): 3.23e-17: 86.4: 41.98		HSP76_HUMAN (1-643): 0: 970: 100.00
+	Hs
		714093 BAG5_HUMAN (418-498): 3.23e-17: 86.4: 41.98		HS71L_HUMAN (1-643): 0: 960: 79.32
+	Dm
		505107 Q9VU81_DROME (398-498): 1.2e-26: 116: 32.11		HSP7D_DROME (4-614): 0: 923: 79.38
+	Dm
		65601 A8JNS4_DROME (398-498): 1.33e-26: 116: 32.11		HSP7D_DROME (4-614): 0: 923: 79.38
+	Hs
		504937 BAG5_HUMAN (418-498): 3.23e-17: 86.4: 41.98		HSP7C_HUMAN (4-615): 0: 940: 79.25
+	Hs
		871826 BAG5_HUMAN (418-498): 3.23e-17: 86.4: 41.98		HSP72_HUMAN (3-643): 0: 925: 77.45