HitPredict

Interactor 1: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Interactor 2: VPS45 (Q9NRW7)
Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)
Gene: VPS45

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Sec1~Synaptobrevin
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 116 Hs			1 570
+	Hs
		278566 VAMP4_HUMAN (3-73): 1.95e-25: 94.6: 29.58		VPS45_HUMAN (1-570): 0: 647: 100.00
+	Hs
		1154761 VAMP3_HUMAN (2-72): 1.48e-24: 91.1: 38.03		VPS45_HUMAN (1-570): 0: 647: 100.00
+	At
		1421789 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		KEULE_ARATH (8-562): 1.05e-156: 465: 21.14
+	Hs
		125732 VAMP2_HUMAN (2-75): 3.53e-25: 93: 39.19		STXB3_HUMAN (22-552): 9.07e-161: 473: 19.44
+	Dm
		1172793 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		SLY1_DROME (1-556): 1.78e-145: 435: 20.44
+	Hs
		328711 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		SCFD1_HUMAN (18-553): 2.29e-141: 425: 20.10
+	Sc
		751579 SNC2_YEAST (2-73): 1.07e-23: 89.6: 23.61		VPS45_YEAST (1-549): 3.05e-152: 451: 36.33
+	Dm
		614896 SYB_DROME (2-88): 1.37e-29: 105: 39.08		SLY1_DROME (1-556): 1.78e-145: 435: 20.44
+	Hs
		278539 VAMP4_HUMAN (3-73): 1.95e-25: 94.6: 29.58		SCFD1_HUMAN (18-553): 2.29e-141: 425: 20.10
+	Sc
		646183 SNC2_YEAST (2-73): 1.07e-23: 89.6: 23.61		SLY1_YEAST (12-560): 9.9e-129: 393: 19.11
+	Sc
		646179 SNC1_YEAST (2-72): 7.82e-22: 84.6: 21.13		SLY1_YEAST (12-560): 9.9e-129: 393: 19.11
+	Sc
		720911 SNC2_YEAST (2-73): 1.07e-23: 89.6: 23.61		SEC1_YEAST (2-550): 1.09e-115: 361: 17.53
+	Sc
		720903 SNC1_YEAST (2-72): 7.82e-22: 84.6: 21.13		SEC1_YEAST (2-550): 1.09e-115: 361: 17.53
+	Tt
		107527 G0S5G3_CHATD (2-91): 3.77e-31: 111: 27.78		G0SCM5_CHATD (15-491): 1.47e-55: 202: 19.50