HitPredict

Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FHA~PH, PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 779
+	Hs
		682210 AKT2_HUMAN (62-535): 1.04e-140: 417: 23.08		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682023 AKT1_HUMAN (62-535): 8.03e-139: 412: 21.58		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		566481 KPCA_HUMAN (44-542): 6.5e-132: 400: 21.11		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		408682 KPCB_HUMAN (44-535): 2.7e-131: 399: 20.80		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		568795 KAPCA_HUMAN (178-536): 3.21e-129: 382: 29.32		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		610780 KAPCB_HUMAN (178-537): 6.63e-129: 382: 28.96		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1039170 KCC2D_HUMAN (215-486): 5.35e-122: 369: 37.96		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1083228 KCC4_HUMAN (215-538): 1.09e-121: 368: 37.54		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		331308 CHK2_HUMAN (1-543): 1.66e-175: 508: 100.00		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		331306 CHK2_HUMAN (1-543): 1.66e-175: 508: 100.00		CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81
+	Hs
		681831 AKT1_HUMAN (62-535): 8.03e-139: 412: 21.58		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Sc
		606187 RAD53_YEAST (115-487): 1.82e-123: 383: 33.02		OSH2_YEAST (2-703): 2.25e-55: 208: 10.89
+	Rn
		1144020 AKT3_RAT (62-535): 1.12e-135: 403: 22.04		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		566377 KPCA_HUMAN (44-542): 6.5e-132: 400: 21.11		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		568704 KAPCA_HUMAN (178-536): 3.21e-129: 382: 29.32		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		408612 KPCB_HUMAN (44-535): 2.7e-131: 399: 20.80		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Mm
		933111 KAPCB_MOUSE (178-536): 1.67e-128: 380: 28.49		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Hs
		1022390 KCC2D_HUMAN (215-486): 5.35e-122: 369: 37.96		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		568798 KAPCA_HUMAN (178-536): 3.21e-129: 382: 29.32		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		787158 KCC2D_HUMAN (215-486): 5.35e-122: 369: 37.96		RHG25_HUMAN (30-181): 1.01e-21: 102: 23.27