HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 2347
+	Hs
		477266 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ROS1_HUMAN (1-2347): 0: 2843: 100.00
+	Hs
		332878 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		EPHA3_HUMAN (1373-2238): 0: 612: 19.65
+	Hs
		332936 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		EPHA5_HUMAN (1369-2290): 0: 601: 19.18
+	Hs
		710668 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		EPHA3_HUMAN (1373-2238): 0: 612: 19.65
+	Hs
		332879 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		EPHA8_HUMAN (1381-2242): 0: 583: 18.48
+	Hs
		710769 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		EPHA8_HUMAN (1381-2242): 0: 583: 18.48
+	Hs
		332828 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		INSR_HUMAN (1424-2308): 8.35e-168: 557: 23.23
+	Hs
		332831 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		IGF1R_HUMAN (1442-2307): 3.32e-163: 544: 22.98
+	Hs
		439866 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		INSR_HUMAN (1424-2308): 8.35e-168: 557: 23.23
+	Hs
		465674 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		IGF1R_HUMAN (1442-2307): 3.32e-163: 544: 22.98
+	Hs
		332850 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		INSRR_HUMAN (1442-2261): 1.19e-155: 520: 24.39
+	Hs
		332881 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		UFO_HUMAN (1633-2297): 3.66e-130: 435: 25.83
+	Hs
		333255 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		ALK_HUMAN (1858-2311): 4.33e-84: 309: 38.96
+	Hs
		1453843 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		ALK_HUMAN (1858-2311): 4.33e-84: 309: 38.96
+	Hs
		332830 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		RET_HUMAN (1940-2216): 6.43e-64: 241: 42.76
+	Hs
		332869 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		FGFR3_HUMAN (1886-2215): 4.24e-59: 222: 38.73
+	Hs
		464067 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		RET_HUMAN (1940-2216): 6.43e-64: 241: 42.76
+	Hs
		464013 MSPD2_HUMAN (4-182): 2.16e-38: 141: 25.41		RET_HUMAN (1940-2216): 6.43e-64: 241: 42.76