HitPredict

Interactor 1: ABL1 (P00520)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: ABI1 (Q8CBW3)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	11163214
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0017124 - SH3 domain binding GO:0030426 - growth cone GO:0031252 - cell leading edge GO:0043005 - neuron projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1123 Mm			1 481
+	Hs
		337502 ABL1_HUMAN (1-1123): 0: 925: 85.88		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		337572 ABL1_HUMAN (1-1123): 0: 925: 85.88		ABI2_HUMAN (1-481): 2.09e-72: 239: 61.79
+	Hs
		789078 ABL2_HUMAN (11-1123): 0: 775: 50.90		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		337590 ABL1_HUMAN (1-1123): 0: 925: 85.88		ASAP1_HUMAN (59-478): 1.09e-35: 143: 16.91
+	Mm
		70555 B2RQ57_MOUSE (11-1123): 0: 690: 49.42		ABI1_MOUSE (1-481): 7.25e-118: 356: 100.00
+	Hs
		789094 ABL2_HUMAN (11-1123): 0: 775: 50.90		ABI2_HUMAN (1-481): 2.09e-72: 239: 61.79
+	Hs
		789066 ABL2_HUMAN (11-1123): 0: 775: 50.90		SRC8_HUMAN (263-475): 1.97e-33: 134: 21.27
+	Hs
		433413 YES_HUMAN (5-510): 0: 542: 39.42		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		523060 SRC_HUMAN (36-510): 0: 541: 39.96		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		412258 FYN_HUMAN (44-510): 5.28e-178: 534: 40.76		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		996567 ITK_HUMAN (44-499): 4.44e-175: 529: 35.50		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Ce
		371307 ABL1_CAEEL (15-1123): 0: 614: 31.73		Q10929_CAEEL (1-476): 1.28e-68: 228: 31.74
+	Dm
		337662 ABL_DROME (38-1073): 0: 582: 38.33		Q9Y0S9_DROME (1-477): 6.31e-70: 232: 35.98
+	Hs
		523197 SRC_HUMAN (36-510): 0: 541: 39.96		ASAP1_HUMAN (59-478): 1.09e-35: 143: 16.91
+	Hs
		412404 FYN_HUMAN (44-510): 5.28e-178: 534: 40.76		ASAP1_HUMAN (59-478): 1.09e-35: 143: 16.91
+	Hs
		433350 YES_HUMAN (5-510): 0: 542: 39.42		SRC8_HUMAN (263-475): 1.97e-33: 134: 21.27
+	Hs
		522981 SRC_HUMAN (36-510): 0: 541: 39.96		SRC8_HUMAN (263-475): 1.97e-33: 134: 21.27
+	Mm
		763381 FYN_MOUSE (44-510): 8.2e-178: 533: 40.76		HCLS1_MOUSE (200-476): 5.2e-30: 124: 22.74
+	Hs
		203198 LCK_HUMAN (9-508): 1.6e-174: 524: 38.49		SYNJ1_HUMAN (38-402): 7.12e-31: 129: 15.16
+	Mm
		411921 LCK_MOUSE (9-508): 9.88e-176: 527: 38.10		HCLS1_MOUSE (200-476): 5.2e-30: 124: 22.74