HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	22973453, 34718347
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007173 - epidermal growth factor receptor signaling pathway GO:0019901 - protein kinase binding GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 532
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (85-526): 8.09e-90: 295: 15.52
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (84-526): 4.42e-86: 285: 15.27
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (81-526): 4.93e-78: 264: 14.77
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (317-527): 2.74e-57: 200: 20.00
+	Hs
		338331 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITK_HUMAN (232-527): 1.19e-54: 196: 18.10
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (351-528): 1.55e-46: 172: 24.32
+	Hs
		337912 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (347-531): 4.7e-49: 178: 18.46
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (345-527): 5.44e-48: 176: 21.65
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (366-528): 8.94e-48: 175: 19.53
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (351-528): 1.16e-46: 172: 24.32
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (349-527): 4.62e-45: 168: 19.37
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (381-532): 9.12e-42: 158: 21.12
+	Hs
		338080 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MATK_HUMAN (398-525): 4.78e-36: 142: 30.37
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (394-525): 1.94e-28: 119: 28.78
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (427-513): 2.66e-13: 71: 29.89
+	Hs
		338093 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KSYK_HUMAN (412-531): 6.62e-17: 86: 30.00
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (427-513): 2.66e-13: 71: 29.89