HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RIN1 (Q13671)
Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)
Gene: RIN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	12783862, 17403676
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 783
+	Hs
		383793 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RIN1_HUMAN (1-783): 0: 734: 100.00
+	Hs
		338768 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RIN2_HUMAN (50-705): 0: 578: 29.43
+	Hs
		383902 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RIN2_HUMAN (50-705): 0: 578: 29.43
+	Hs
		339105 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RABX5_HUMAN (285-630): 4.38e-97: 312: 14.21
+	Rn
		94037 Q9QX70_RAT (1-1210): 0: 1241: 90.34		F1LN91_RAT (28-227): 2.13e-43: 172: 18.98
+	Hs
		338552 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS3_HUMAN (28-227): 4.82e-43: 171: 20.37
+	Hs
		338550 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS2_HUMAN (4-230): 1.01e-38: 157: 18.60
+	Hs
		339003 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS1_HUMAN (10-225): 3.96e-37: 152: 16.46
+	Hs
		338683 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS4_HUMAN (2-214): 1.14e-35: 146: 17.67
+	Hs
		181754 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS1_HUMAN (49-192): 1.35e-26: 110: 24.32
+	Hs
		338983 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SLAP2_HUMAN (19-170): 5.44e-26: 109: 18.64
+	Hs
		1070975 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS3_HUMAN (28-227): 4.82e-43: 171: 20.37
+	Hs
		1070974 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS2_HUMAN (4-230): 1.01e-38: 157: 18.60
+	Hs
		1071015 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS1_HUMAN (10-225): 3.96e-37: 152: 16.46
+	Hs
		1070981 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS4_HUMAN (2-214): 1.14e-35: 146: 17.67
+	Hs
		383853 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TENS3_HUMAN (28-227): 4.82e-43: 171: 20.37
+	Hs
		383851 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TENS2_HUMAN (4-230): 1.01e-38: 157: 18.60
+	Hs
		181866 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		SOCS1_HUMAN (49-192): 1.35e-26: 110: 24.32
+	Hs
		1071013 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		SLAP2_HUMAN (19-170): 5.44e-26: 109: 18.64
+	Hs
		181758 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		SOCS1_HUMAN (49-192): 1.35e-26: 110: 24.32