HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RAPH1 (Q70E73)
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)
Gene: RAPH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24076656
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1250
+	Hs
		338431 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB14_HUMAN (160-604): 2.08e-146: 455: 25.28
+	Hs
		338370 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		338432 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		383805 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRB14_HUMAN (160-604): 2.08e-146: 455: 25.28
+	Hs
		1031667 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		1054054 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		383780 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		383806 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		601921 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		337875 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97
+	Hs
		338769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TITIN_HUMAN (586-1241): 1.11e-11: 71.9: 13.92
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97
+	Hs
		383583 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97
+	Hs
		554266 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97
+	Hs
		434223 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		RAPH1_HUMAN (1-1250): 0: 627: 100.00
+	Hs
		434186 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		434194 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		872612 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		872614 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		872640 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95