HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: TNPO1 (Q92973)
Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
Gene: TNPO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	35384245, 23956138
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 898
+	Hs
		155507 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TNPO2_HUMAN (11-898): 0: 613: 84.30
+	Hs
		383912 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TNPO1_HUMAN (1-898): 0: 663: 100.00
+	Hs
		127154 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO5_HUMAN (21-879): 2.71e-91: 314: 16.85
+	Hs
		338445 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IMB1_HUMAN (21-862): 1.01e-87: 300: 16.15
+	Hs
		338188 EGFR_HUMAN (1-1210): 0: 1241: 100.00		XPO2_HUMAN (14-897): 9.98e-87: 299: 12.98
+	Hs
		312152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO7_HUMAN (21-851): 6.08e-77: 273: 14.49
+	Hs
		383812 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IMB1_HUMAN (21-862): 1.01e-87: 300: 16.15
+	Hs
		338740 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO4_HUMAN (33-772): 2e-27: 122: 17.91
+	Hs
		435716 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		TNPO1_HUMAN (1-898): 0: 663: 100.00
+	Mm
		796521 ZAP70_MOUSE (718-961): 2.03e-52: 197: 40.00		XPO2_MOUSE (14-897): 4.05e-87: 300: 13.08