HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LRIG1 (Q96JA1)
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)
Gene: LRIG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.921

Property	Details
Experiments	20126551, 15345710, 15282549, 18542056, 16847455
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, far western blotting, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_4, GF_recep_IV~LRR_8, LRR_4~PK_Tyr_Ser-Thr, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1093
+	Mm
		936212 EGFR_MOUSE (1-1210): 0: 1258: 90.35		LRIG1_MOUSE (50-1093): 0: 693: 82.29
+	Hs
		1070999 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRIG1_HUMAN (1-1093): 0: 736: 97.72
+	Hs
		383933 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRIG1_HUMAN (1-1093): 0: 736: 97.72
+	Hs
		601975 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		LRIG1_HUMAN (1-1093): 0: 736: 97.72
+	Mm
		964570 EGFR_MOUSE (1-1210): 0: 1258: 90.35		LIGO1_MOUSE (143-585): 3.04e-32: 135: 29.26
+	Hs
		338012 EGFR_HUMAN (1-1210): 0: 1241: 100.00		L1CAM_HUMAN (482-839): 3.36e-32: 138: 19.02
+	Hs
		338833 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LIGO1_HUMAN (143-585): 1.57e-31: 134: 29.04
+	Hs
		338583 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG3_HUMAN (861-1091): 5.36e-12: 72.5: 9.80
+	Hs
		299545 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG2_HUMAN (863-1091): 3.23e-10: 66.7: 11.07
+	Rn
		984693 Q8K3F9_RAT (5-1200): 0: 1129: 48.85		L1CAM_RAT (482-839): 1.44e-33: 142: 21.32
+	Hs
		383644 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		L1CAM_HUMAN (482-839): 3.36e-32: 138: 19.02
+	Hs
		601825 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		L1CAM_HUMAN (482-839): 3.36e-32: 138: 19.02
+	Rn
		984692 ERBB3_RAT (1-1180): 0: 1070: 41.32		L1CAM_RAT (482-839): 1.44e-33: 142: 21.32
+	Hs
		1070977 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRIG3_HUMAN (861-1091): 5.36e-12: 72.5: 9.80
+	Hs
		383860 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRIG3_HUMAN (861-1091): 5.36e-12: 72.5: 9.80
+	At
		84503 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		GSO1_ARATH (6-466): 1.48e-101: 349: 20.99
+	At
		1338064 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		RGI1_ARATH (35-477): 2.28e-95: 330: 18.91
+	At
		1352201 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		Y1723_ARATH (100-478): 3.58e-72: 263: 18.44
+	At
		221803 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME1_ARATH (163-476): 1.76e-57: 218: 20.51
+	At
		1341092 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME2_ARATH (305-448): 4.63e-25: 114: 26.39