HitPredict

Interactor 1: THRB (P00734)
Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
Gene: F2

Interactor 2: ANT3 (P01008)
Antithrombin-III (ATIII) (Serpin C1)
Gene: SERPINC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 28743742, 2013320
Identification Methods comigration in gel electrophoresis, comigration in sds page
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Serpin~Trypsin
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005788 - endoplasmic reticulum lumen
GO:0005886 - plasma membrane
GO:0007596 - blood coagulation
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 622
Hs

1 464
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024