Protein: NECT2
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)

Gene: NECT2, NECTIN2
Organism: Homo sapiens
Interactions: 171
UniProt ID: Q92692

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0001675 - acrosome assembly
GO:0002860 - positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891 - positive regulation of immunoglobulin mediated immune response
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1366764

NECT2
Nectin-2

7

17

Small-scale

0.968

High

1366784

NECT3
Nectin-3

6

17

Small-scale

0.952

High

1193158

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

3

3

Small-scale

0.879

High

375796

RASK
GTPase KRas

4

20

High-throughput

0.873

High

374107

RASN
GTPase NRas

3

20

High-throughput

0.827

High

374822

RASH
GTPase HRas

3

20

High-throughput

0.827

High

1309607

SPA12
Serpin A12

2

2

High-throughput

0.811

High

1286851

TM11B
Transmembrane protease serine 11B

2

15

High-throughput

0.789

High

452352

PDIA1
Protein disulfide-isomerase

2

5

High-throughput

0.783

High

1153418

CD226
CD226 antigen

2

18

Small-scale

0.768

High

540602

LAMP1
Lysosome-associated membrane glycoprotein 1

2

4

High-throughput

0.754

High

976465

RB11A
Ras-related protein Rab-11A

2

7

High-throughput

0.754

High

978207

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

652376

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

0

High-throughput

0.742

High

1277339

NT2NA
Notch homolog 2 N-terminal-like protein A

2

20

High-throughput

0.731

High

1366770

NECT4
Nectin-4

1

18

Small-scale

0.724

High

936403

AFAD
Afadin

5

20

Small-scale

0.710

High

1366786

PICK1
PRKCA-binding protein

4

5

Small-scale

0.702

High

369485

AACT
Alpha-1-antichymotrypsin

1

2

High-throughput

0.691

High

437752

HEPS
Serine protease hepsin

1

15

High-throughput

0.691

High

580811

PVR
Poliovirus receptor

1

17

High-throughput

0.691

High

663503

PRPH2
Peripherin-2

1

3

High-throughput

0.691

High

749372

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

3

High-throughput

0.691

High

1366767

HVCN1
Voltage-gated hydrogen channel 1

1

2

High-throughput

0.691

High

1366773

TMPSD
Transmembrane protease serine 13

1

15

High-throughput

0.691

High

1366794

CLC4A
C-type lectin domain family 4 member A

1

17

High-throughput

0.691

High

1366798

ST14
Suppressor of tumorigenicity 14 protein

1

15

High-throughput

0.691

High

1356472

TB22A
TBC1 domain family member 22A

3

2

High-throughput

0.667

High

456973

GP1BA
Platelet glycoprotein Ib alpha chain

1

20

High-throughput

0.665

High

1258066

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.663

High

1227182

A16L1
Autophagy-related protein 16-1

2

5

High-throughput

0.659

High

1366772

MDFI
MyoD family inhibitor

4

1

High-throughput

0.644

High

1366778

DNJC5
DnaJ homolog subfamily C member 5

2

7

High-throughput

0.634

High

423814

APOD
Apolipoprotein D

2

1

High-throughput

0.628

High

1187209

CC50B
Cell cycle control protein 50B

2

1

High-throughput

0.628

High

126729

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

341117

DIRA3
GTP-binding protein Di-Ras3

1

8

High-throughput

0.618

High

363659

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

376533

LDLR
Low-density lipoprotein receptor

1

3

High-throughput

0.618

High

410976

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

466392

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

556256

CADH1
Cadherin-1

1

4

High-throughput

0.618

High

581211

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601394

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

630919

RAB4A
Ras-related protein Rab-4A

1

10

High-throughput

0.618

High

631387

RAB5A
Ras-related protein Rab-5A

1

10

High-throughput

0.618

High

643002

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.618

High

693047

DPP4
Dipeptidyl peptidase 4

1

3

High-throughput

0.618

High

710404

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

774529

BASI
Basigin

1

19

High-throughput

0.618

High

787222

BMR1A
Bone morphogenetic protein receptor type-1A

1

5

High-throughput

0.618

High

845742

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.618

High

900964

RAB5C
Ras-related protein Rab-5C

1

10

High-throughput

0.618

High

901450

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.618

High

901982

RAB9A
Ras-related protein Rab-9A

1

11

High-throughput

0.618

High

910153

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

945061

RAB25
Ras-related protein Rab-25

1

8

High-throughput

0.618

High

953600

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955440

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

956432

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.618

High

962340

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

962798

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

988582

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1004150

CXAR
Coxsackievirus and adenovirus receptor

1

18

High-throughput

0.618

High

1015648

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1145046

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.618

High

1151806

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1270929

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1366779

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1366781

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1366792

ZO2
Tight junction protein 2

1

10

High-throughput

0.618

High

1366796

LAMP3
Lysosome-associated membrane glycoprotein 3

1

4

High-throughput

0.618

High

70396

CRTP1
Cysteine-rich tail protein 1

2

3

High-throughput

0.606

High

303171

RGS20
Regulator of G-protein signaling 20

2

2

High-throughput

0.606

High

1364907

NR4A3
Nuclear receptor subfamily 4 group A member 3

2

7

High-throughput

0.606

High

926512

SYRC
Arginine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.602

High

1366774

LOXE3
Hydroperoxide isomerase ALOXE3

2

0

High-throughput

0.602

High

517076

NT2NC
Notch homolog 2 N-terminal-like protein C

1

20

High-throughput

0.594

High

1161168

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.587

High

975160

ARF6
ADP-ribosylation factor 6

2

5

High-throughput

0.584

High

722562

CTR1
High affinity cationic amino acid transporter 1

1

6

High-throughput

0.575

High

948898

CD81
CD81 antigen

1

10

High-throughput

0.575

High

1048375

ACVR1
Activin receptor type-1

1

5

High-throughput

0.575

High

1366768

MF14A
Hippocampus abundant transcript 1 protein

1

5

High-throughput

0.575

High

1366785

S17A5
Sialin

1

2

High-throughput

0.575

High

1366776

BTBD1
BTB/POZ domain-containing protein 1

2

9

High-throughput

0.574

High

587163

ITF2
Transcription factor 4

2

1

High-throughput

0.553

High

885352

HXA1
Homeobox protein Hox-A1

2

4

High-throughput

0.553

High

948367

KR122
Keratin-associated protein 12-2

2

20

High-throughput

0.553

High

950610

KR108
Keratin-associated protein 10-8

2

20

High-throughput

0.553

High

1059707

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.553

High

1213913

LCE1C
Late cornified envelope protein 1C

2

1

High-throughput

0.553

High

1215188

LCE2C
Late cornified envelope protein 2C

2

1

High-throughput

0.553

High

1307428

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.553

High

1146442

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.553

High

1186222

CEA21
Cell adhesion molecule CEACAM21

1

18

High-throughput

0.553

High

1254888

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

1366769

LRRC7
Leucine-rich repeat-containing protein 7

1

3

Small-scale

0.553

High

698968

CALX
Calnexin

1

14

High-throughput

0.536

High

761279

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.536

High

1245899

BRID5
BRICHOS domain-containing protein 5

1

4

High-throughput

0.536

High

1275317

PLPR4
Phospholipid phosphatase-related protein type 4

1

3

High-throughput

0.536

High

1366766

T106A
Transmembrane protein 106A

1

4

High-throughput

0.536

High

1366795

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

1

1

High-throughput

0.536

High

685920

KRA59
Keratin-associated protein 5-9

1

20

High-throughput

0.523

High

950354

KR107
Keratin-associated protein 10-7

1

20

High-throughput

0.523

High

1307760

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

High-throughput

0.523

High

1366783

LYRM4
LYR motif-containing protein 4

1

0

High-throughput

0.518

High

1361627

SSH1
Protein phosphatase Slingshot homolog 1

1

10

High-throughput

0.515

High

1308924

S22A9
Organic anion transporter 7

1

3

High-throughput

0.514

High

1248716

SBSN
Suprabasin

1

0

High-throughput

0.513

High

1366775

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.513

High

288279

SPAG6
Sperm-associated antigen 6

1

1

High-throughput

0.489

High

1366777

CST11
Cystatin-11

1

1

High-throughput

0.489

High

1366793

RSP14
Radial spoke head 14 homolog

1

4

High-throughput

0.489

High

181724

CTDSL
CTD small phosphatase-like protein

1

4

High-throughput

0.479

High

189754

STX7
Syntaxin-7

1

7

High-throughput

0.479

High

218572

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

299318

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

327390

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.479

High

463688

LYN
Tyrosine-protein kinase Lyn

1

13

High-throughput

0.479

High

604136

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

691303

1433T
14-3-3 protein theta

1

7

High-throughput

0.479

High

715702

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.479

High

730114

1433B
14-3-3 protein beta/alpha

1

7

High-throughput

0.479

High

941824

ARL4C
ADP-ribosylation factor-like protein 4C

1

20

High-throughput

0.479

High

966697

1433G
14-3-3 protein gamma

1

7

High-throughput

0.479

High

986605

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

990567

1433Z
14-3-3 protein zeta/delta

1

7

High-throughput

0.479

High

1039973

AKA12
A-kinase anchor protein 12

1

3

High-throughput

0.479

High

1041207

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

1049637

1433F
14-3-3 protein eta

1

7

High-throughput

0.479

High

1087227

STX4
Syntaxin-4

1

7

High-throughput

0.479

High

1159783

OCLN
Occludin

1

3

High-throughput

0.479

High

1233393

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1249071

LMBRL
Protein LMBR1L

1

5

High-throughput

0.479

High

1322926

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

1326500

ARL14
ADP-ribosylation factor-like protein 14

1

9

High-throughput

0.479

High

1353236

PARD3
Partitioning defective 3 homolog

1

19

High-throughput

0.479

High

1366765

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.479

High

1366771

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

1366780

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1366788

ARL15
ADP-ribosylation factor-like protein 15

1

9

High-throughput

0.479

High

1366789

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

1366791

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

950107

KR105
Keratin-associated protein 10-5

1

20

High-throughput

0.470

High

1232495

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

1366790

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1366797

FUT9
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

1

0

High-throughput

0.458

High

1249424

OLFM4
Olfactomedin-4

1

3

High-throughput

0.445

High

594

NBPFJ
NBPF family member NBPF19

1

10

High-throughput

0.439

High

894065

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

949757

KR101
Keratin-associated protein 10-1

1

20

High-throughput

0.439

High

949956

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

1213998

LCE1E
Late cornified envelope protein 1E

1

1

High-throughput

0.439

High

139949

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.437

High

294112

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

827236

ARL1
ADP-ribosylation factor-like protein 1

1

6

High-throughput

0.437

High

1187518

AR13B
ADP-ribosylation factor-like protein 13B

1

7

High-throughput

0.437

High

1289257

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

1

High-throughput

0.437

High

1293099

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1366782

E41LA
Band 4.1-like protein 4A

1

8

High-throughput

0.437

High

582352

ARSA
Arylsulfatase A

1

0

High-throughput

0.426

High

1160709

DREB
Drebrin

1

2

Small-scale

0.407

High

1219239

SYPL2
Synaptophysin-like protein 2

2

0

High-throughput

0.328

High

159082

LCE2B
Late cornified envelope protein 2B

2

0

High-throughput

0.316

High

1215946

LCE5A
Late cornified envelope protein 5A

2

0

High-throughput

0.316

High

939812

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.282

High

1366787

DUS2
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

1

0

High-throughput

0.282

High

1214043

LCE1F
Late cornified envelope protein 1F

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025