HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: FHR1 (Q03591)
Complement factor H-related protein 1 (FHR-1) (H factor-like protein 1) (FHL-1) (H-factor-like 1) (H36)
Gene: CFHR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32034129
Identification Methods	solid phase assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006956 - complement activation GO:0032991 - protein-containing complex GO:0072562 - blood microparticle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1663 Hs			1 330
+	Hs
		344662 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR3_HUMAN (1-328): 5.49e-87: 266: 40.18
+	Hs
		344697 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR4_HUMAN (1-329): 2.44e-62: 209: 34.41
+	Hs
		344710 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR5_HUMAN (7-328): 2.43e-49: 174: 32.13
+	Hs
		344619 CO3_HUMAN (1-1663): 0: 2219: 100.00		F13B_HUMAN (5-330): 7.44e-43: 158: 26.09
+	Hs
		344636 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR1_HUMAN (3-259): 1.54e-34: 136: 17.82
+	Hs
		344624 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAH_HUMAN (24-328): 1.67e-32: 129: 21.41
+	Hs
		344632 CO3_HUMAN (1-1663): 0: 2219: 100.00		MCP_HUMAN (4-206): 5.27e-25: 105: 14.95
+	Hs
		341566 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAB_HUMAN (16-165): 5.06e-13: 71.7: 18.59
+	Hs
		344638 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR2_HUMAN (2-146): 3.35e-11: 66.4: 16.99
+	Mm
		344735 CO3_MOUSE (1-1663): 0: 2139: 76.77		CFAH_MOUSE (5-329): 2.39e-31: 126: 18.69
+	Hs
		469908 CO4B_HUMAN (16-1661): 0: 1625: 28.37		FHR4_HUMAN (1-329): 2.44e-62: 209: 34.41
+	Hs
		469878 CO4A_HUMAN (16-1661): 0: 1624: 28.20		FHR4_HUMAN (1-329): 2.44e-62: 209: 34.41
+	Hs
		416130 CO4B_HUMAN (16-1661): 0: 1625: 28.37		CO2_HUMAN (1-215): 7.17e-34: 133: 17.11
+	Hs
		416129 CO4A_HUMAN (16-1661): 0: 1624: 28.20		CO2_HUMAN (1-215): 7.17e-34: 133: 17.11
+	Hs
		344753 CO5_HUMAN (10-1661): 0: 1664: 27.73		CO6_HUMAN (79-329): 5.59e-12: 68.7: 17.58
+	Hs
		469899 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MCP_HUMAN (4-206): 5.27e-25: 105: 14.95
+	Hs
		344406 A2MG_HUMAN (19-1498): 0: 1369: 23.02		F13B_HUMAN (5-330): 7.44e-43: 158: 26.09