HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	16410719, 20308430, 28205554, 35013218, 17289033, 23277542
Identification Methods	affinity chromatography technology, pull down, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 156
+	Hs
		346157 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		347918 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33
+	Hs
		347606 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11
+	Mm
		348423 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		EHMT1_MOUSE (4-119): 1.01e-30: 118: 20.51
+	Hs
		346158 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CDN2C_HUMAN (21-135): 1.37e-25: 97.4: 28.21
+	Hs
		257540 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ANR17_HUMAN (69-147): 2.99e-19: 85.1: 20.25
+	Hs
		345768 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		POTEJ_HUMAN (49-152): 1.44e-18: 83.1: 13.89
+	Hs
		347264 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ANKH1_HUMAN (68-155): 3.32e-18: 82.3: 19.32
+	Hs
		346844 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ANKR1_HUMAN (47-155): 1.2e-17: 79.2: 21.10
+	Hs
		347626 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ANR27_HUMAN (2-85): 2.82e-15: 73.8: 21.59
+	Hs
		347839 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TANC1_HUMAN (56-154): 1.3e-14: 71.9: 21.00
+	Hs
		348210 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		348100 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		RAI14_HUMAN (1-64): 1.97e-11: 62.7: 21.21
+	Hs
		166872 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22
+	Hs
		379102 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00
+	Hs
		257544 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ANR17_HUMAN (69-147): 2.99e-19: 85.1: 20.25
+	Hs
		378944 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		POTEI_HUMAN (49-152): 1.58e-18: 83.1: 13.89
+	Dm
		1362732 MYC_DROME (210-454): 3.25e-30: 126: 26.74		ANKHM_DROME (64-155): 4.91e-18: 81.9: 19.57