Protein: UBP51
Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51)

Gene: UBP51, USP51
Organism: Homo sapiens
Interactions: 49
UniProt ID: Q70EK9

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005694 - chromosome
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1135624

AT7L3
Ataxin-7-like protein 3

3

4

High-throughput

0.855

High

67133

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

2

16

High-throughput

0.789

High

1258107

ENY2
Transcription and mRNA export factor ENY2

2

3

High-throughput

0.789

High

790062

ZEB1
Zinc finger E-box-binding homeobox 1

3

5

Small-scale

0.678

High

1258108

PD1L1
Programmed cell death 1 ligand 1

1

11

Small-scale

0.648

High

1258105

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

15

High-throughput

0.647

High

1258109

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

17

High-throughput

0.647

High

1258111

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

19

High-throughput

0.647

High

284963

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

15

High-throughput

0.618

High

1258110

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

16

High-throughput

0.618

High

549185

CDK4
Cyclin-dependent kinase 4

1

9

Small-scale

0.578

High

1025375

CDK6
Cyclin-dependent kinase 6

1

7

Small-scale

0.578

High

1162809

H2A2C
Histone H2A type 2-C

1

16

Small-scale

0.561

High

1258100

DGCR8
Microprocessor complex subunit DGCR8

1

1

Small-scale

0.561

High

1147191

ELOB
Elongin-B

1

1

Small-scale

0.553

High

595806

H13
Histone H1.3

1

6

High-throughput

0.536

High

938113

ANM2
Protein arginine N-methyltransferase 2

1

1

High-throughput

0.536

High

1028251

MDM2
E3 ubiquitin-protein ligase Mdm2

1

10

High-throughput

0.536

High

1258096

AHNK2
Protein AHNAK2

1

6

High-throughput

0.536

High

1058097

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

1131743

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.513

High

1258097

JMY
Junction-mediating and -regulatory protein

1

0

High-throughput

0.513

High

419043

H2A1B
Histone H2A type 1-B/E

1

16

Small-scale

0.501

High

754885

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.501

High

1258099

PJA1
E3 ubiquitin-protein ligase Praja-1

1

9

High-throughput

0.501

High

469738

GSTA1
Glutathione S-transferase A1

1

2

High-throughput

0.489

High

1258102

SH3K1
SH3 domain-containing kinase-binding protein 1

1

11

High-throughput

0.489

High

1258112

CD2AP
CD2-associated protein

1

11

High-throughput

0.489

High

184722

ATX7
Ataxin-7

1

14

High-throughput

0.479

High

284839

TADA3
Transcriptional adapter 3

1

4

High-throughput

0.479

High

319157

ST65G
STAGA complex 65 subunit gamma

1

2

High-throughput

0.479

High

1151962

TWST1
Twist-related protein 1

1

5

Small-scale

0.479

High

1161310

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.479

High

1258095

TAD2B
Transcriptional adapter 2-beta

1

9

High-throughput

0.479

High

1258098

SP20H
Transcription factor SPT20 homolog

1

2

High-throughput

0.479

High

1258101

KAT2B
Histone acetyltransferase KAT2B

1

13

High-throughput

0.479

High

1258103

TADA1
Transcriptional adapter 1

1

3

High-throughput

0.479

High

1258113

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

3

High-throughput

0.479

High

822728

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

983856

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

662350

VAMP1
Vesicle-associated membrane protein 1

1

3

High-throughput

0.437

High

989347

VAMP2
Vesicle-associated membrane protein 2

1

4

High-throughput

0.437

High

1112889

CUL2
Cullin-2

1

6

Small-scale

0.437

High

1154659

VAMP3
Vesicle-associated membrane protein 3

1

3

High-throughput

0.437

High

1213417

AT7L2
Ataxin-7-like protein 2

1

9

High-throughput

0.437

High

1250350

FAT4
Protocadherin Fat 4

1

4

Small-scale

0.437

High

1258104

SGF29
SAGA-associated factor 29

1

3

High-throughput

0.437

High

1258106

TAF9B
Transcription initiation factor TFIID subunit 9B

1

5

High-throughput

0.437

High

1147058

ELOC
Elongin-C

1

0

Small-scale

0.292

High


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Last updated: 11Aug2025