HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: HELLS (Q9NRZ9)
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
Gene: HELLS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	30415952, 17314511, 17353931
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0044027 - negative regulation of gene expression via chromosomal CpG island methylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 838
+	Hs
		348113 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD7_HUMAN (31-836): 0: 657: 27.28
+	Hs
		347951 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD8_HUMAN (2-836): 0: 635: 26.71
+	Hs
		346268 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		346805 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Hs
		347406 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD5_HUMAN (50-835): 0: 627: 24.83
+	Mm
		348422 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		SMCA4_MOUSE (9-838): 0: 636: 25.42
+	Mm
		348432 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		CHD4_MOUSE (51-828): 0: 629: 25.39
+	Hs
		346938 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD9_HUMAN (3-836): 0: 619: 26.49
+	Hs
		229271 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		151469 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD2_HUMAN (5-830): 0: 596: 27.25
+	Hs
		346003 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA1_HUMAN (104-833): 0: 596: 31.06
+	Hs
		346267 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		379973 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		CHD7_HUMAN (31-836): 0: 657: 27.28
+	Hs
		379142 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		379411 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Hs
		229276 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		151473 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		CHD2_HUMAN (5-830): 0: 596: 27.25
+	Hs
		379141 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		347218 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD1L_HUMAN (218-755): 1.8e-105: 347: 40.30
+	Hs
		347888 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMRCD_HUMAN (206-744): 1.53e-92: 315: 37.59