Protein: S12A3
Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter)

Gene: S12A3, SLC12A3
Organism: Homo sapiens
Interactions: 72
UniProt ID: P55017

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006811 - monoatomic ion transport
GO:0006814 - sodium ion transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

536832

HSP7C
Heat shock cognate 71 kDa protein

2

13

Small-scale

0.611

High

461312

HS90A
Heat shock protein HSP 90-alpha

2

16

Small-scale

0.571

High

679116

DNJB1
DnaJ homolog subfamily B member 1

2

7

Small-scale

0.571

High

731124

STIP1
Stress-induced-phosphoprotein 1

2

11

Small-scale

0.571

High

933547

CHIP
E3 ubiquitin-protein ligase CHIP

2

6

Small-scale

0.571

High

933535

DDRGK
DDRGK domain-containing protein 1

2

1

High-throughput

0.549

High

255404

SNX2
Sorting nexin-2

1

3

High-throughput

0.536

High

933512

GCYB1
Guanylate cyclase soluble subunit beta-1

1

3

High-throughput

0.536

High

933516

SNX1
Sorting nexin-1

1

3

High-throughput

0.536

High

933548

SNX6
Sorting nexin-6

1

3

High-throughput

0.536

High

933551

SNX5
Sorting nexin-5

1

3

High-throughput

0.536

High

717417

PDIA3
Protein disulfide-isomerase A3

1

2

Small-scale

0.481

High

861533

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

2

Small-scale

0.479

High

933528

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

933510

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.458

High

933533

HAVR1
Hepatitis A virus cellular receptor 1

1

0

Small-scale

0.458

High

933545

KLHL3
Kelch-like protein 3

1

0

Small-scale

0.458

High

50528

HACL2
2-hydroxyacyl-CoA lyase 2

1

3

High-throughput

0.445

High

124759

AIP
AH receptor-interacting protein

1

9

High-throughput

0.445

High

291274

NU155
Nuclear pore complex protein Nup155

1

3

High-throughput

0.445

High

343923

HS74L
Heat shock 70 kDa protein 4L

1

20

High-throughput

0.445

High

346928

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.445

High

347601

BAG3
BAG family molecular chaperone regulator 3

1

9

High-throughput

0.445

High

468219

HS90B
Heat shock protein HSP 90-beta

1

16

High-throughput

0.445

High

531026

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

2

High-throughput

0.445

High

600781

HSP76
Heat shock 70 kDa protein 6

1

14

High-throughput

0.445

High

749880

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.445

High

761356

HS71L
Heat shock 70 kDa protein 1-like

1

13

High-throughput

0.445

High

761607

HSP74
Heat shock 70 kDa protein 4

1

20

High-throughput

0.445

High

894651

EMD
Emerin

1

2

High-throughput

0.445

High

916632

PPP5
Serine/threonine-protein phosphatase 5

1

1

High-throughput

0.445

High

930834

HSP72
Heat shock-related 70 kDa protein 2

1

14

High-throughput

0.445

High

933513

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

16

High-throughput

0.445

High

933514

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

2

High-throughput

0.445

High

933515

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

16

High-throughput

0.445

High

933517

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

16

High-throughput

0.445

High

933521

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

1

High-throughput

0.445

High

933523

RETST
All-trans-retinol 13,14-reductase

1

4

High-throughput

0.445

High

933525

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

2

High-throughput

0.445

High

933526

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

2

High-throughput

0.445

High

933527

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

2

High-throughput

0.445

High

933529

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.445

High

933530

SCFD1
Sec1 family domain-containing protein 1

1

3

High-throughput

0.445

High

933531

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.445

High

933532

ASTRA
Protein Aster-A

1

1

High-throughput

0.445

High

933536

DNJC7
DnaJ homolog subfamily C member 7

1

16

High-throughput

0.445

High

933538

ABCA3
Phospholipid-transporting ATPase ABCA3

1

1

High-throughput

0.445

High

933539

ESYT1
Extended synaptotagmin-1

1

4

High-throughput

0.445

High

933540

RPAP3
RNA polymerase II-associated protein 3

1

12

High-throughput

0.445

High

933544

DNJB4
DnaJ homolog subfamily B member 4

1

7

High-throughput

0.445

High

933546

BAG5
BAG family molecular chaperone regulator 5

1

9

High-throughput

0.445

High

933549

SGT1
Protein SGT1 homolog

1

4

High-throughput

0.445

High

61096

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.426

High

187043

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.426

High

316372

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.426

High

716473

DOPD
D-dopachrome decarboxylase

1

0

High-throughput

0.426

High

933511

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.426

High

933518

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.426

High

933519

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.426

High

933524

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

0

High-throughput

0.426

High

933537

METH
Methionine synthase

1

0

High-throughput

0.426

High

933552

TX264
Testis-expressed protein 264

1

0

High-throughput

0.426

High

280164

SC22B
Vesicle-trafficking protein SEC22b

1

2

High-throughput

0.407

High

346621

TTC4
Tetratricopeptide repeat protein 4

1

20

High-throughput

0.407

High

933541

DJC18
DnaJ homolog subfamily C member 18

1

15

High-throughput

0.407

High

933550

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.407

High

895520

SERPH
Serpin H1

1

0

High-throughput

0.232

Low

933520

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

0

High-throughput

0.232

Low

933522

RADX
RPA-related protein RADX

1

0

High-throughput

0.232

Low

933534

KBP
KIF-binding protein

1

0

High-throughput

0.232

Low

933542

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.232

Low

933543

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025