Protein: S12A6
Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)

Gene: S12A6, SLC12A6
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q9UHW9

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0005886 - plasma membrane
GO:0006811 - monoatomic ion transport
GO:0006884 - cell volume homeostasis
GO:0007268 - chemical synaptic transmission

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460114

S12A4
Solute carrier family 12 member 4

5

13

Small-scale

0.908

High

1460119

S12A7
Solute carrier family 12 member 7

2

12

Small-scale

0.737

High

609835

LEG3
Galectin-3

5

20

Small-scale

0.712

High

127410

LEG8
Galectin-8

4

20

Small-scale

0.694

High

1155201

EREP1
Endosomal transmembrane epsin interactor 1

3

4

High-throughput

0.667

High

125653

LEG9
Galectin-9

5

20

High-throughput

0.650

High

1459051

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

3

12

Small-scale

0.633

High

142162

NPT3
Sodium-dependent phosphate transport protein 3

2

3

High-throughput

0.628

High

821781

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

3

High-throughput

0.628

High

845548

PI2R
Prostacyclin receptor

2

8

High-throughput

0.628

High

1406367

GPR21
Probable G-protein coupled receptor 21

2

8

High-throughput

0.628

High

1428338

NMUR2
Neuromedin-U receptor 2

2

9

High-throughput

0.628

High

1446233

NRN1
Neuritin

2

2

High-throughput

0.628

High

1448885

RAB6B
Ras-related protein Rab-6B

4

20

Small-scale

0.619

High

1460110

S12A6
Solute carrier family 12 member 6

1

12

Small-scale

0.618

High

1231709

LEG9C
Galectin-9C

3

20

High-throughput

0.609

High

1180871

S4A8
Electroneutral sodium bicarbonate exchanger 1

2

0

High-throughput

0.602

High

171009

CLGN
Calmegin

3

11

Small-scale

0.593

High

1432286

S12A5
Solute carrier family 12 member 5

1

13

High-throughput

0.575

High

1359369

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

7

High-throughput

0.574

High

178855

SCAM1
Secretory carrier-associated membrane protein 1

2

6

Small-scale

0.571

High

347981

BAG3
BAG family molecular chaperone regulator 3

2

10

Small-scale

0.571

High

631709

RAB6A
Ras-related protein Rab-6A

2

20

Small-scale

0.571

High

789975

FDFT
Squalene synthase

2

1

Small-scale

0.571

High

1158593

CDC37
Hsp90 co-chaperone Cdc37

2

3

Small-scale

0.571

High

1405902

DNJC7
DnaJ homolog subfamily C member 7

2

16

Small-scale

0.571

High

1460112

BAG5
BAG family molecular chaperone regulator 5

2

10

Small-scale

0.571

High

913684

VAV2
Guanine nucleotide exchange factor VAV2

1

1

Small-scale

0.561

High

339615

ACSL3
Fatty acid CoA ligase Acsl3

2

0

Small-scale

0.547

High

297378

DYSF
Dysferlin

1

4

High-throughput

0.541

High

248518

O10H2
Olfactory receptor 10H2

1

11

High-throughput

0.536

High

480922

LEG1
Galectin-1

1

20

High-throughput

0.536

High

1185828

PTHD3
Patched domain-containing protein 3

1

3

High-throughput

0.536

High

1195466

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

2

High-throughput

0.536

High

1203826

TTMP
TPA-induced transmembrane protein

1

4

High-throughput

0.536

High

1216664

OR2G6
Olfactory receptor 2G6

1

3

High-throughput

0.536

High

1277747

TMC4
Voltage-gated chloride channel TMC4

1

2

High-throughput

0.536

High

1328496

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

4

High-throughput

0.536

High

1339993

O10S1
Olfactory receptor 10S1

1

9

High-throughput

0.536

High

1392594

S41A3
Solute carrier family 41 member 3

1

2

High-throughput

0.536

High

1393221

TM169
Transmembrane protein 169

1

1

High-throughput

0.536

High

1432446

TTYH1
Protein tweety homolog 1

1

5

High-throughput

0.536

High

1438492

RXFP1
Relaxin receptor 1

1

5

High-throughput

0.536

High

1446133

KCMB3
Calcium-activated potassium channel subunit beta-3

1

1

High-throughput

0.536

High

1460117

O10H1
Olfactory receptor 10H1

1

11

High-throughput

0.536

High

1460118

PCDGL
Protocadherin gamma-C4

1

6

High-throughput

0.536

High

344036

HS74L
Heat shock 70 kDa protein 4L

2

20

Small-scale

0.521

High

679280

DNJB1
DnaJ homolog subfamily B member 1

2

6

Small-scale

0.521

High

731679

STIP1
Stress-induced-phosphoprotein 1

2

12

Small-scale

0.521

High

1200382

RAB6D
Ras-related protein Rab-6D

2

20

Small-scale

0.521

High

1328223

JAGN1
Protein jagunal homolog 1

2

3

Small-scale

0.521

High

1460113

CHIP
E3 ubiquitin-protein ligase CHIP

2

7

Small-scale

0.521

High

1234230

OR2A2
Olfactory receptor 2A2

1

3

High-throughput

0.515

High

1254052

R9BP
Regulator of G-protein signaling 9-binding protein

1

0

High-throughput

0.513

High

984580

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.493

High

49825

CLRN2
Clarin-2

1

3

High-throughput

0.489

High

317096

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

2

High-throughput

0.489

High

1126383

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

4

High-throughput

0.489

High

1185368

LEG9B
Galectin-9B

1

20

High-throughput

0.489

High

1392310

ZDH12
Palmitoyltransferase ZDHHC12

1

7

High-throughput

0.489

High

1454018

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

1454527

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

4

High-throughput

0.489

High

50727

HACL2
2-hydroxyacyl-CoA lyase 2

1

5

Small-scale

0.479

High

133814

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.479

High

178585

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

8

Small-scale

0.479

High

178995

SCAM2
Secretory carrier-associated membrane protein 2

1

6

Small-scale

0.479

High

189914

STX7
Syntaxin-7

1

14

High-throughput

0.479

High

218928

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

226250

STX6
Syntaxin-6

1

8

High-throughput

0.479

High

347395

BAG2
BAG family molecular chaperone regulator 2

1

2

Small-scale

0.479

High

376067

RASK
GTPase KRas

1

20

High-throughput

0.479

High

420851

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

4

Small-scale

0.479

High

463825

LYN
Tyrosine-protein kinase Lyn

1

9

High-throughput

0.479

High

630661

RAB3B
Ras-related protein Rab-3B

1

14

High-throughput

0.479

High

631540

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.479

High

690421

STOM
Stomatin

1

4

Small-scale

0.479

High

699238

CALX
Calnexin

1

11

Small-scale

0.479

High

710553

EPHA2
Ephrin type-A receptor 2

1

18

High-throughput

0.479

High

774692

BASI
Basigin

1

6

Small-scale

0.479

High

901090

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.479

High

901655

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.479

High

958045

RAB14
Ras-related protein Rab-14

1

20

Small-scale

0.479

High

978383

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

1015887

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1041356

CAV1
Caveolin-1

1

5

High-throughput

0.479

High

1087333

STX4
Syntaxin-4

1

15

High-throughput

0.479

High

1133963

RB39A
Ras-related protein Rab-39A

1

20

Small-scale

0.479

High

1145158

RAB35
Ras-related protein Rab-35

1

17

Small-scale

0.479

High

1151921

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1207908

S27A3
Long-chain fatty acid transport protein 3

1

6

Small-scale

0.479

High

1233555

LTOR1
Ragulator complex protein LAMTOR1

1

6

High-throughput

0.479

High

1271039

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1371985

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

5

Small-scale

0.479

High

1395881

CLP1L
Lipid scramblase CLPTM1L

1

2

Small-scale

0.479

High

1404269

SEC62
Translocation protein SEC62

1

5

Small-scale

0.479

High

1406733

SGMR1
Sigma non-opioid intracellular receptor 1

1

2

Small-scale

0.479

High

1408209

RNF5
E3 ubiquitin-protein ligase RNF5

1

4

Small-scale

0.479

High

1446033

RAB9B
Ras-related protein Rab-9B

1

20

Small-scale

0.479

High

1450325

CC50A
Cell cycle control protein 50A

1

2

Small-scale

0.479

High

1452165

DJB12
DnaJ homolog subfamily B member 12

1

14

Small-scale

0.479

High

1460111

AMFR
E3 ubiquitin-protein ligase AMFR

1

4

Small-scale

0.479

High

1460116

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

5

Small-scale

0.479

High

1460120

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

2

Small-scale

0.479

High

553292

KCRB
Creatine kinase B-type

1

0

Small-scale

0.473

High

961580

VA0D1
V-type proton ATPase subunit d 1

1

0

Small-scale

0.458

High

1155282

VAS1
V-type proton ATPase subunit S1

1

0

Small-scale

0.458

High

1242471

CNNM4
Metal transporter CNNM4

1

0

Small-scale

0.458

High

324231

CE152
Centrosomal protein of 152 kDa

1

1

High-throughput

0.445

High

462015

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.445

High

468886

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.445

High

484238

PGFRB
Platelet-derived growth factor receptor beta

1

6

High-throughput

0.445

High

510092

S352B
Solute carrier family 35 member E2B

1

1

High-throughput

0.445

High

600955

HSP76
Heat shock 70 kDa protein 6

1

14

High-throughput

0.445

High

761533

HS71L
Heat shock 70 kDa protein 1-like

1

14

High-throughput

0.445

High

1010119

DLK1
Protein delta homolog 1

1

9

High-throughput

0.445

High

1134182

NTCP
Hepatic sodium/bile acid cotransporter

1

4

High-throughput

0.445

High

1244123

TMM88
Transmembrane protein 88

1

1

High-throughput

0.445

High

1309006

S22A9
Organic anion transporter 7

1

3

High-throughput

0.445

High

1438431

POPD2
Popeye domain-containing protein 2

1

3

High-throughput

0.445

High

283385

ERLN1
Erlin-1

1

2

Small-scale

0.437

High

298971

DNJB5
DnaJ homolog subfamily B member 5

1

6

Small-scale

0.437

High

631009

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.437

High

956530

RAB2A
Ras-related protein Rab-2A

1

20

High-throughput

0.437

High

1186382

S2535
Solute carrier family 25 member 35

1

1

High-throughput

0.437

High

1293192

TMM17
Transmembrane protein 17

1

6

High-throughput

0.437

High

1333720

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

Small-scale

0.437

High

1357344

THEM6
Protein THEM6

1

2

Small-scale

0.437

High

1386407

FAF2
FAS-associated factor 2

1

3

Small-scale

0.437

High

1460115

DJC16
DnaJ homolog subfamily C member 16

1

14

Small-scale

0.437

High

1336044

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.426

High

761918

HSP74
Heat shock 70 kDa protein 4

1

20

High-throughput

0.407

High

1365260

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.407

High

596407

H12
Histone H1.2

1

0

High-throughput

0.269

Low

230133

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

Small-scale

0.249

Low

244783

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

Small-scale

0.249

Low

1331319

S2529
Mitochondrial basic amino acids transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025