HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RASA1 (P20936)
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)
Gene: RASA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 10669731
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~Pkinase
Common GO terms GO:0001953 - negative regulation of cell-matrix adhesion
GO:0005737 - cytoplasm
GO:0035556 - intracellular signal transduction
GO:0043066 - negative regulation of apoptotic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1239
Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025