Protein: NEK1
Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)

Gene: NEK1
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q96PY6

Gene Ontology (top 5):
GO:0000242 - pericentriolar material
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1292800

SKAP1
Src kinase-associated phosphoprotein 1

3

20

High-throughput

0.861

High

1209534

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

18

Small-scale

0.799

High

1182855

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

14

High-throughput

0.778

High

1049686

1433F
14-3-3 protein eta

5

20

Small-scale

0.716

High

730165

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.709

High

1400381

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

20

High-throughput

0.692

High

1110542

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

11

High-throughput

0.691

High

1122317

SCRIB
Protein scribble homolog

1

13

High-throughput

0.691

High

1241884

NEK5
Serine/threonine-protein kinase Nek5

1

19

High-throughput

0.691

High

966768

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

691350

1433T
14-3-3 protein theta

4

20

High-throughput

0.678

High

228921

CF410
Cilia- and flagella-associated protein 410

3

14

Small-scale

0.674

High

1358984

TEKT4
Tektin-4

3

2

High-throughput

0.667

High

1400368

ZN350
Zinc finger protein 350

1

4

Small-scale

0.656

High

1194111

VP26B
Vacuolar protein sorting-associated protein 26B

3

0

High-throughput

0.638

High

1326637

KIF2B
Kinesin-like protein KIF2B

2

11

High-throughput

0.628

High

1390811

CPNE2
Copine-2

2

5

High-throughput

0.628

High

1398990

ODAD4
Outer dynein arm-docking complex subunit 4

2

12

High-throughput

0.628

High

1400363

ALS2
Alsin

2

8

High-throughput

0.628

High

658925

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

9

Small-scale

0.619

High

521417

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.618

High

891291

GSK3A
Glycogen synthase kinase-3 alpha

1

20

High-throughput

0.618

High

891746

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.618

High

1400370

MYNN
Myoneurin

1

6

High-throughput

0.618

High

1400372

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.618

High

971902

1433E
14-3-3 protein epsilon

2

20

High-throughput

0.611

High

990626

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1400366

WDR83
WD repeat domain-containing protein 83

3

12

High-throughput

0.609

High

391418

FRIL
Ferritin light chain

2

6

High-throughput

0.601

High

1331174

ZN615
Zinc finger protein 615

1

1

Small-scale

0.590

High

1400362

NEK1
Serine/threonine-protein kinase Nek1

1

16

Small-scale

0.590

High

1005372

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

5

Small-scale

0.579

High

399614

VTNC
Vitronectin

2

3

High-throughput

0.574

High

862391

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.561

High

1327140

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.553

High

1400365

FEZ1
Fasciculation and elongation protein zeta-1

1

1

Small-scale

0.552

High

1400376

FEZ2
Fasciculation and elongation protein zeta-2

1

1

Small-scale

0.552

High

1400378

PNMA2
Paraneoplastic antigen Ma2

2

6

High-throughput

0.549

High

158584

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

9

High-throughput

0.536

High

549666

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

3

High-throughput

0.536

High

682581

S100P
Protein S100-P

1

12

High-throughput

0.536

High

994736

YBOX1
Y-box-binding protein 1

1

8

High-throughput

0.515

High

1400364

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

1400374

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.513

High

855503

ATRX
Transcriptional regulator ATRX

1

11

Small-scale

0.508

High

890878

TSC2
Tuberin

1

2

Small-scale

0.508

High

1088978

TP53B
TP53-binding protein 1

1

5

Small-scale

0.508

High

1400371

EXOS4
Exosome complex component RRP41

1

1

High-throughput

0.508

High

1400375

CTNL1
Alpha-catulin

1

4

Small-scale

0.508

High

1400380

KIF3A
Kinesin-like protein KIF3A

1

7

Small-scale

0.508

High

1399046

TMM74
Transmembrane protein 74

1

3

High-throughput

0.489

High

892919

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.486

High

1143901

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

4

Small-scale

0.481

High

173247

XPO1
Exportin-1

1

20

High-throughput

0.479

High

177043

CE290
Centrosomal protein of 290 kDa

1

20

High-throughput

0.479

High

246877

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.479

High

348672

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.479

High

372892

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.479

High

406532

MYCN
N-myc proto-oncogene protein

1

14

High-throughput

0.479

High

419145

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.479

High

459724

PROF1
Profilin-1

1

3

High-throughput

0.479

High

1053727

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

12

High-throughput

0.479

High

1109492

ATR
Serine/threonine-protein kinase ATR

1

18

Small-scale

0.479

High

1110002

HDAC1
Histone deacetylase 1

1

15

High-throughput

0.479

High

1181492

EMAL3
Echinoderm microtubule-associated protein-like 3

1

19

High-throughput

0.479

High

1228457

FTM
Protein fantom

1

20

High-throughput

0.479

High

1276662

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.479

High

1289549

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1365338

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

1384415

PF21A
PHD finger protein 21A

1

11

High-throughput

0.479

High

1390697

DYL2
Dynein light chain 2, cytoplasmic

1

12

High-throughput

0.479

High

1400367

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1400377

RCOR1
REST corepressor 1

1

8

High-throughput

0.479

High

1400379

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.479

High

245355

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.458

High

1360340

ATRIP
ATR-interacting protein

1

0

Small-scale

0.458

High

437501

CASB
Beta-casein

1

2

Small-scale

0.457

High

1131701

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

4

Small-scale

0.457

High

58907

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

6

High-throughput

0.445

High

239178

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.445

High

1258550

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

9

High-throughput

0.445

High

1400369

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

9

High-throughput

0.445

High

106500

APRIO
Alternative prion protein

1

10

High-throughput

0.437

High

1203772

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1231252

REP15
Rab15 effector protein

1

0

High-throughput

0.279

Low

1238250

CK087
Uncharacterized protein C11orf87

1

0

High-throughput

0.279

Low

1400373

SPAT7
Spermatogenesis-associated protein 7

1

0

High-throughput

0.279

Low

377694

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025