Protein: M4K3
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)

Gene: M4K3, MAP4K3
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q8IVH8

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1308767

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

4

17

High-throughput

0.896

High

1308738

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

2

15

Small-scale

0.737

High

1048289

KPCT
Protein kinase C theta type

1

20

Small-scale

0.734

High

987753

GRB2
Growth factor receptor-bound protein 2

6

20

High-throughput

0.730

High

333083

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

4

High-throughput

0.628

High

1178563

ZN423
Zinc finger protein 423

1

2

High-throughput

0.618

High

375694

RASK
GTPase KRas

1

20

High-throughput

0.618

High

412216

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

710351

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

1087668

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

15

High-throughput

0.618

High

1100876

G3BP1
Ras GTPase-activating protein-binding protein 1

1

9

High-throughput

0.618

High

1158414

CDC37
Hsp90 co-chaperone Cdc37

1

9

High-throughput

0.618

High

1254520

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1308755

G3BP2
Ras GTPase-activating protein-binding protein 2

1

10

High-throughput

0.618

High

1094308

LCP2
Lymphocyte cytosolic protein 2

1

5

Small-scale

0.569

High

1308746

SH3G1
Endophilin-A2

1

20

High-throughput

0.561

High

955957

RAB8A
Ras-related protein Rab-8A

1

9

Small-scale

0.559

High

1308766

LOXL2
Lysyl oxidase homolog 2

2

2

High-throughput

0.558

High

187376

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

1

High-throughput

0.553

High

374034

RASN
GTPase NRas

1

20

High-throughput

0.553

High

471878

RU2B
U2 small nuclear ribonucleoprotein B''

1

8

High-throughput

0.553

High

909621

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

10

High-throughput

0.553

High

1308740

CSN5
COP9 signalosome complex subunit 5

1

11

High-throughput

0.541

High

1308748

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

High-throughput

0.541

High

1308752

ITSN2
Intersectin-2

1

8

High-throughput

0.541

High

977133

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.517

High

1146728

PCBP1
Poly(rC)-binding protein 1

1

6

High-throughput

0.515

High

994288

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

20

High-throughput

0.501

High

1308751

STRN4
Striatin-4

1

20

High-throughput

0.501

High

1280031

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.494

High

1008599

I13R1
Interleukin-13 receptor subunit alpha-1

1

11

High-throughput

0.489

High

437259

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

445952

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

476745

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.479

High

594039

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

711376

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

855899

CRKL
Crk-like protein

1

20

High-throughput

0.479

High

859348

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.479

High

961771

RL37A
Large ribosomal subunit protein eL43

1

3

High-throughput

0.479

High

966576

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

984460

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.479

High

1131066

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

10

High-throughput

0.479

High

1252457

LN28B
Protein lin-28 homolog B

1

6

High-throughput

0.479

High

1308739

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

1308747

SH3G3
Endophilin-A3

1

20

High-throughput

0.479

High

1308750

GAN
Gigaxonin

1

4

High-throughput

0.479

High

1308753

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1308754

DBNL
Drebrin-like protein

1

15

High-throughput

0.479

High

1308765

RL36
Large ribosomal subunit protein eL36

1

4

High-throughput

0.479

High

1308768

SNX9
Sorting nexin-9

1

6

High-throughput

0.479

High

1308744

FCRL3
Fc receptor-like protein 3

1

3

High-throughput

0.470

High

635341

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

2

High-throughput

0.445

High

66697

RTL1
Retrotransposon-like protein 1

1

1

High-throughput

0.437

High

372499

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.437

High

974421

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

High-throughput

0.437

High

1011480

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.437

High

1011835

RT05
Small ribosomal subunit protein uS5m

1

1

High-throughput

0.437

High

1012209

RT11
Small ribosomal subunit protein uS11m

1

2

High-throughput

0.437

High

1012544

RT34
Small ribosomal subunit protein mS34

1

1

High-throughput

0.437

High

1012889

RT09
Small ribosomal subunit protein uS9m

1

1

High-throughput

0.437

High

1041158

CAV1
Caveolin-1

1

7

High-throughput

0.437

High

1159739

OCLN
Occludin

1

7

High-throughput

0.437

High

1246131

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

17

High-throughput

0.437

High

1308741

COA7
Cytochrome c oxidase assembly factor 7

1

5

High-throughput

0.437

High

1308742

PTER
N-acetyltaurine hydrolase

1

1

High-throughput

0.437

High

1308745

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.437

High

1308760

RT02
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.437

High

1308761

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.437

High

1308762

NOP16
Nucleolar protein 16

1

1

High-throughput

0.437

High

1308763

RT16
Small ribosomal subunit protein bS16m

1

2

High-throughput

0.437

High

1308764

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.437

High

1308749

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.292

High

256325

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.249

Low

902520

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.249

Low

973969

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.249

Low

1011307

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.249

Low

1011654

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.249

Low

1012720

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.249

Low

1308743

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.249

Low

1308756

RT33
Small ribosomal subunit protein mS33

1

0

High-throughput

0.249

Low

1308757

RT28
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.249

Low

1308758

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.249

Low

1308759

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.249

Low

1308769

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025