HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: KDIS (Q9ULH0)
Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
Gene: KIDINS220

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras, Ank_2~Ras, Ank_4~Ras
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1771
+	Hs
		350674 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		1070450 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		914450 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		895318 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Dm
		1248518 Q962I2_DROME (4-170): 1.83e-59: 186: 51.79		Q8SWY2_DROME (1-465): 9.94e-134: 445: 23.44
+	Hs
		350675 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ANR50_HUMAN (1-307): 2.84e-80: 295: 31.27
+	Hs
		349001 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		ANR50_HUMAN (1-307): 2.84e-80: 295: 31.27
+	Hs
		350123 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		1021405 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		350083 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Hs
		349253 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Dm
		65552 RALA_DROME (4-169): 1.5e-59: 186: 52.70		A8JNM5_DROME (191-505): 7.26e-65: 247: 18.21
+	Hs
		349212 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		DAPK1_HUMAN (4-305): 4.92e-35: 149: 31.58
+	Hs
		862018 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		DAPK1_HUMAN (4-305): 4.92e-35: 149: 31.58