HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: USH1G (Q495M9)
pre-mRNA splicing regulator USH1G (Scaffold protein containing ankyrin repeats and SAM domain) (Usher syndrome type-1G protein)
Gene: USH1G

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 461
+	Hs
		350083 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ANK2_HUMAN (3-410): 4.21e-61: 217: 12.97
+	Hs
		350123 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ANK3_HUMAN (3-402): 2.02e-60: 215: 12.90
+	Hs
		349253 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		ANK2_HUMAN (3-410): 4.21e-61: 217: 12.97
+	Hs
		349000 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Hs
		350674 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Hs
		349001 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ANR50_HUMAN (46-372): 2.65e-37: 147: 12.36
+	Dm
		1248518 Q962I2_DROME (4-181): 2.02e-61: 191: 50.82		Q8SWY2_DROME (1-399): 1.09e-58: 210: 13.86
+	Hs
		350675 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ANR50_HUMAN (46-372): 2.65e-37: 147: 12.36
+	Hs
		348910 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		TANC1_HUMAN (13-360): 7.9e-33: 134: 13.35
+	Hs
		914450 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Hs
		350525 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		TANC1_HUMAN (13-360): 7.9e-33: 134: 13.35
+	Dm
		65552 RALA_DROME (4-167): 1.35e-61: 191: 55.15		A8JNM5_DROME (31-378): 1.51e-48: 181: 16.48
+	Hs
		862018 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		DAPK1_HUMAN (4-198): 1.88e-37: 148: 19.18
+	Hs
		349212 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		DAPK1_HUMAN (4-198): 1.88e-37: 148: 19.18
+	Hs
		350402 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		CSKI2_HUMAN (3-69): 5.09e-16: 83: 27.54
+	Hs
		349533 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		CSKI2_HUMAN (3-69): 5.09e-16: 83: 27.54
+	Hs
		297230 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		DDHD2_HUMAN (355-453): 1.06e-10: 65.9: 38.61