HitPredict

Interactor 1: CBX7 (O95931)
Chromobox protein homolog 7
Gene: CBX7

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	19706751
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 251 Hs			1 488
+	Hs
		1368217 CDYL_HUMAN (2-250): 1.54e-48: 170: 19.93		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		853360 CBX5_HUMAN (11-165): 5.65e-43: 146: 20.48		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1097462 CBX3_HUMAN (9-157): 2.46e-42: 144: 22.00		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1014174 CBX1_HUMAN (17-157): 2.3e-39: 136: 23.13		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		236515 SUV91_MOUSE (11-126): 1.19e-32: 124: 24.37		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		216501 SUV91_HUMAN (11-125): 2e-30: 118: 23.73		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1110203 CDYL_HUMAN (2-250): 1.54e-48: 170: 19.93		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		148627 SUV91_MOUSE (11-126): 1.19e-32: 124: 24.37		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		216430 SUV91_HUMAN (11-125): 2e-30: 118: 23.73		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		683685 PC_DROME (10-73): 1.4e-18: 85.7: 53.13		HDAC1_DROME (5-472): 0: 653: 77.92
+	Ce
		112830 CBXH1_CAEEL (8-161): 6.5e-38: 132: 25.00		HDA1_CAEEL (7-456): 0: 595: 64.02
+	Mm
		236511 SUV91_MOUSE (11-126): 1.19e-32: 124: 24.37		HDAC3_MOUSE (10-431): 0: 574: 58.49
+	Hs
		188111 SUV91_HUMAN (11-125): 2e-30: 118: 23.73		HDAC3_HUMAN (10-431): 0: 574: 58.26