HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	17043313, 19217406, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 131 Sc			1 562
+	Sc
		355733 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		SIR2_YEAST (1-562): 0: 847: 100.00
+	Sc
		355572 H2B1_YEAST (1-131): 2.54e-44: 143: 100.00		HST1_YEAST (113-560): 0: 582: 66.81
+	Hs
		918599 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		SIR1_HUMAN (202-525): 7.26e-102: 325: 37.76
+	Hs
		1087425 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SIR7_HUMAN (174-535): 1.51e-93: 293: 19.30
+	Hs
		420888 H2B1J_HUMAN (7-128): 5.77e-46: 146: 70.16		SIR7_HUMAN (174-535): 1.51e-93: 293: 19.30
+	Hs
		1307144 H2B1L_HUMAN (7-128): 2.46e-44: 142: 70.16		SIR7_HUMAN (174-535): 1.51e-93: 293: 19.30
+	Hs
		617959 H2B1O_HUMAN (7-128): 2.09e-46: 148: 70.97		SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95
+	Hs
		241589 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95
+	Hs
		886160 H2B1D_HUMAN (7-128): 1.99e-45: 145: 70.16		SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95