HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~PHD
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 726
+	Hs
		355431 NSD2_HUMAN (1-1365): 0: 988: 100.00		BRD2_HUMAN (5-700): 8.79e-139: 429: 57.95
+	Mm
		1297458 NSD2_MOUSE (1-1365): 0: 998: 90.92		BRD4_MOUSE (3-644): 4.15e-103: 346: 53.82
+	Hs
		259273 NSD2_HUMAN (1-1365): 0: 988: 100.00		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		1141291 NSD3_HUMAN (116-1340): 0: 764: 45.27		BRD3_HUMAN (1-702): 1.03e-155: 470: 100.00
+	Hs
		674318 NSD3_HUMAN (116-1340): 0: 764: 45.27		BRD2_HUMAN (5-700): 8.79e-139: 429: 57.95
+	Hs
		1201960 NSD3_HUMAN (116-1340): 0: 764: 45.27		BRDT_HUMAN (18-694): 2.86e-116: 374: 49.78
+	Hs
		260413 NSD3_HUMAN (116-1340): 0: 764: 45.27		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		1141141 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		BRD3_HUMAN (1-702): 1.03e-155: 470: 100.00
+	Hs
		674177 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		BRD2_HUMAN (5-700): 8.79e-139: 429: 57.95
+	Hs
		260501 ASH1L_HUMAN (924-1232): 1.68e-58: 225: 31.75		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		260008 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		1146232 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		ZMY11_HUMAN (3-446): 3.19e-46: 176: 10.15
+	Dm
		567654 ASH1_DROME (991-1237): 9.71e-67: 251: 37.65		FSH_DROME (277-481): 4.64e-28: 123: 26.21
+	Sc
		863944 SET2_YEAST (972-1208): 1.23e-61: 227: 35.12		GCN5_YEAST (284-417): 7.16e-37: 145: 31.88
+	Hs
		1067381 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		EP300_HUMAN (4-177): 1.06e-35: 148: 23.43
+	Hs
		1155617 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		KAT2B_HUMAN (267-414): 8.84e-32: 134: 25.50
+	Hs
		1447966 ASH1L_HUMAN (924-1232): 1.68e-58: 225: 31.75		BRPF3_HUMAN (20-316): 1.15e-29: 128: 14.29
+	Hs
		1155721 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		CECR2_HUMAN (130-557): 3.68e-29: 126: 14.78
+	Hs
		1155511 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		PB1_HUMAN (152-486): 2.23e-20: 99.1: 12.85
+	Hs
		1155592 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		PHIP_HUMAN (5-702): 1.66e-17: 89.5: 11.03