HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: KAT2B (Q92831)
Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)
Gene: KAT2B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	25800736
Identification Methods	enzymatic study, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription and 1 others more... GO:0048511 - rhythmic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 832
+	Hs
		674177 EZH2_HUMAN (1-746): 0: 864: 100.00		BRD2_HUMAN (661-830): 7.68e-36: 147: 23.12
+	Hs
		1086771 EZH2_HUMAN (1-746): 0: 864: 100.00		BPTF_HUMAN (725-825): 5.75e-35: 146: 47.53
+	Hs
		1155721 EZH2_HUMAN (1-746): 0: 864: 100.00		CECR2_HUMAN (716-826): 3.83e-35: 146: 35.14
+	Hs
		1141141 EZH2_HUMAN (1-746): 0: 864: 100.00		BRD3_HUMAN (672-830): 8.49e-33: 137: 22.67
+	Hs
		260008 EZH2_HUMAN (1-746): 0: 864: 100.00		BRD4_HUMAN (651-832): 5.08e-32: 136: 20.73
+	Hs
		1155511 EZH2_HUMAN (1-746): 0: 864: 100.00		PB1_HUMAN (683-826): 7.49e-18: 91: 22.00
+	Mm
		107973 EZH2_MOUSE (1-746): 0: 861: 98.39		G3UWZ0_MOUSE (730-829): 3.01e-10: 66.2: 29.00
+	Hs
		674278 EZH1_HUMAN (15-745): 0: 747: 63.48		BRD2_HUMAN (661-830): 7.68e-36: 147: 23.12
+	Dm
		144551 ASH1_DROME (196-732): 3.18e-100: 341: 18.55		O01368_DROME (698-825): 2.2e-35: 147: 26.72
+	Dm
		567654 ASH1_DROME (196-732): 3.18e-100: 341: 18.55		FSH_DROME (669-830): 1.28e-34: 145: 22.35
+	Hs
		355614 NSD2_HUMAN (275-729): 1.3e-91: 314: 16.03		BAZ2A_HUMAN (643-826): 2.31e-37: 154: 27.72
+	Hs
		355431 NSD2_HUMAN (275-729): 1.3e-91: 314: 16.03		BRD2_HUMAN (661-830): 7.68e-36: 147: 23.12
+	Hs
		1416765 SETD2_HUMAN (190-732): 1.93e-89: 310: 16.64		CECR2_HUMAN (716-826): 3.83e-35: 146: 35.14
+	Mm
		1297458 NSD2_MOUSE (275-729): 8.35e-93: 318: 16.03		BRD4_MOUSE (651-832): 3.02e-32: 137: 21.24
+	Hs
		355526 NSD2_HUMAN (275-729): 1.3e-91: 314: 16.03		BRD3_HUMAN (672-830): 8.49e-33: 137: 22.67
+	Hs
		259273 NSD2_HUMAN (275-729): 1.3e-91: 314: 16.03		BRD4_HUMAN (651-832): 5.08e-32: 136: 20.73
+	Hs
		1141267 NSD1_HUMAN (275-729): 2.84e-90: 312: 15.82		BRD3_HUMAN (672-830): 8.49e-33: 137: 22.67
+	Hs
		260412 SETD2_HUMAN (190-732): 1.93e-89: 310: 16.64		BRD4_HUMAN (651-832): 5.08e-32: 136: 20.73
+	Hs
		260501 ASH1L_HUMAN (356-733): 8.9e-72: 257: 20.66		BRD4_HUMAN (651-832): 5.08e-32: 136: 20.73
+	Hs
		260471 EHMT1_HUMAN (441-732): 1.63e-70: 253: 24.27		BRD4_HUMAN (651-832): 5.08e-32: 136: 20.73