HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: BTC (P35070)
Probetacellulin [Cleaved into: Betacellulin (BTC)]
Gene: BTC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 0.60 0.595

The method score is based on:

Property Details
Experiments 9662041, 28988771
Identification Methods coimmunoprecipitation, x ray scattering
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0030669 - clathrin-coated endocytic vesicle membrane
and 2 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1210
Hs

1 178
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Service provided by Combinatics, Japan

Last updated: 11Aug2025