Protein: TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)]

Gene: TGFA
Organism: Homo sapiens
Interactions: 80
UniProt ID: P01135

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0005154 - epidermal growth factor receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

362548

EGFR
Epidermal growth factor receptor

7

16

Small-scale

0.743

High

226655

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

3

4

High-throughput

0.616

High

376631

NKD2
Protein naked cuticle homolog 2

2

0

Small-scale

0.571

High

376628

RHBL4
Rhomboid-related protein 4

1

1

Small-scale

0.561

High

376604

DLG1
Disks large homolog 1

1

0

Small-scale

0.549

High

171651

GAK
Cyclin-G-associated kinase

1

2

High-throughput

0.536

High

178597

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

1

High-throughput

0.536

High

184959

SPTC2
Serine palmitoyltransferase 2

1

1

High-throughput

0.536

High

250032

ADCY9
Adenylate cyclase type 9

1

1

High-throughput

0.536

High

297045

DHRS3
Short-chain dehydrogenase/reductase 3

1

1

High-throughput

0.536

High

333427

MPZL1
Myelin protein zero-like protein 1

1

1

High-throughput

0.536

High

349353

TSN15
Tetraspanin-15

1

1

High-throughput

0.536

High

376592

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.536

High

376593

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

1

High-throughput

0.536

High

376594

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.536

High

376602

RAB5B
Ras-related protein Rab-5B

1

1

High-throughput

0.536

High

376612

TM63B
Mechanosensitive cation channel TMEM63B

1

1

High-throughput

0.536

High

376620

LAP4B
Lysosomal-associated transmembrane protein 4B

1

1

High-throughput

0.536

High

376621

LSR
Lipolysis-stimulated lipoprotein receptor

1

1

High-throughput

0.536

High

376627

RDH11
Retinol dehydrogenase 11

1

2

High-throughput

0.536

High

376630

GLMN
Glomulin

1

1

High-throughput

0.536

High

376635

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

1

High-throughput

0.536

High

376639

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.536

High

376642

ZDHC6
Palmitoyltransferase ZDHHC6

1

5

High-throughput

0.536

High

376645

RDH14
Retinol dehydrogenase 14

1

2

High-throughput

0.536

High

376646

AT131
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.536

High

376651

DHRS7
Dehydrogenase/reductase SDR family member 7

1

4

High-throughput

0.536

High

376605

SNTA1
Alpha-1-syntrophin

1

2

Small-scale

0.527

High

376636

GORS1
Golgi reassembly-stacking protein 1

1

1

Small-scale

0.527

High

376643

GORS2
Golgi reassembly-stacking protein 2

1

1

Small-scale

0.527

High

376596

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.513

High

376599

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

0

High-throughput

0.513

High

376601

RAC3
Ras-related C3 botulinum toxin substrate 3

1

0

High-throughput

0.513

High

376607

VAMP3
Vesicle-associated membrane protein 3

1

0

High-throughput

0.513

High

376608

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.513

High

376609

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.513

High

376611

S27A3
Long-chain fatty acid transport protein 3

1

0

High-throughput

0.513

High

376614

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.513

High

376615

TM214
Transmembrane protein 214

1

0

High-throughput

0.513

High

376617

DHDDS
Dehydrodolichyl diphosphate synthase complex subunit DHDDS

1

0

High-throughput

0.513

High

376619

NLRX1
NLR family member X1

1

0

High-throughput

0.513

High

376623

DGLB
Diacylglycerol lipase-beta

1

0

High-throughput

0.513

High

376624

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.513

High

376625

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.513

High

376626

TBC15
TBC1 domain family member 15

1

0

High-throughput

0.513

High

376629

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

0

High-throughput

0.513

High

376638

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.513

High

376641

ARV1
Protein ARV1

1

0

High-throughput

0.513

High

376647

PDXL2
Podocalyxin-like protein 2

1

0

High-throughput

0.513

High

376649

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

376650

LCAP
Leucyl-cystinyl aminopeptidase

1

0

High-throughput

0.513

High

376655

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.513

High

376656

S23IP
SEC23-interacting protein

1

0

High-throughput

0.513

High

376613

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

2

Small-scale

0.501

High

376618

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

2

Small-scale

0.501

High

376598

PEX5
Peroxisomal targeting signal 1 receptor

1

2

High-throughput

0.489

High

376610

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

2

High-throughput

0.489

High

376644

XPO5
Exportin-5

1

1

High-throughput

0.489

High

376648

MTCH1
Mitochondrial carrier homolog 1

1

5

High-throughput

0.489

High

376653

TNPO3
Transportin-3

1

2

High-throughput

0.489

High

376654

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.489

High

376603

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

2

Small-scale

0.479

High

376640

RAB34
Ras-related protein Rab-34

1

0

High-throughput

0.458

High

329613

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.316

High

164506

TNPO2
Transportin-2

1

0

High-throughput

0.279

Low

177506

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.279

Low

183115

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.279

Low

231431

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.279

Low

376595

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

High-throughput

0.279

Low

376597

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

376600

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.279

Low

376606

PWP2
Periodic tryptophan protein 2 homolog

1

0

High-throughput

0.279

Low

376616

FRMD5
FERM domain-containing protein 5

1

0

High-throughput

0.279

Low

376622

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.279

Low

376632

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.279

Low

376633

PRR11
Proline-rich protein 11

1

0

High-throughput

0.279

Low

376634

VMA22
Vacuolar ATPase assembly protein VMA22

1

0

High-throughput

0.279

Low

376637

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.279

Low

376652

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.279

Low

376591

NARR
Ras-related protein Rab-34, isoform NARR

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025