HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: S39A6 (Q13433)
Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)
Gene: SLC39A6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0045121 - membrane raft
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 755
+	Hs
		410816 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S39A6_HUMAN (1-755): 0: 620: 100.00
+	Hs
		364013 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39AA_HUMAN (1-755): 4.26e-162: 491: 33.69
+	Hs
		411111 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S39AA_HUMAN (1-755): 4.26e-162: 491: 33.69
+	Hs
		363373 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39AC_HUMAN (392-749): 1.21e-45: 175: 25.55
+	Hs
		363561 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39AB_HUMAN (505-744): 2.07e-37: 145: 18.62
+	Hs
		363932 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39A1_HUMAN (559-742): 3.83e-37: 143: 16.49
+	Hs
		363456 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39A5_HUMAN (226-390): 1.71e-20: 98.1: 30.72
+	Hs
		363644 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39A7_HUMAN (309-627): 7.74e-19: 92.3: 17.19
+	Hs
		410938 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S39AB_HUMAN (505-744): 2.07e-37: 145: 18.62
+	Hs
		410970 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S39A7_HUMAN (309-627): 7.74e-19: 92.3: 17.19
+	Hs
		710223 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		S39A6_HUMAN (1-755): 0: 620: 100.00
+	Hs
		465510 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		S39A6_HUMAN (1-755): 0: 620: 100.00
+	Hs
		710560 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		S39AA_HUMAN (1-755): 4.26e-162: 491: 33.69
+	Hs
		932099 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		S39AB_HUMAN (505-744): 2.07e-37: 145: 18.62
+	Hs
		710870 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		S39A7_HUMAN (309-627): 7.74e-19: 92.3: 17.19
+	Hs
		1147396 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		S39A7_HUMAN (309-627): 7.74e-19: 92.3: 17.19