HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: S39A7 (Q92504)
Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)
Gene: SLC39A7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	28065597, 35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005794 - Golgi apparatus GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 469
+	Hs
		364013 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39AA_HUMAN (35-469): 2e-86: 284: 21.05
+	Hs
		363373 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39AC_HUMAN (97-469): 1.41e-72: 244: 23.40
+	Hs
		410970 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S39A7_HUMAN (1-469): 8.32e-104: 319: 100.00
+	Hs
		363561 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39AB_HUMAN (129-467): 3.12e-49: 173: 15.04
+	Hs
		411111 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S39AA_HUMAN (35-469): 2e-86: 284: 21.05
+	Hs
		363932 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39A1_HUMAN (166-469): 2.67e-39: 146: 17.76
+	Hs
		363456 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39A5_HUMAN (171-445): 1.91e-33: 134: 30.55
+	Hs
		363231 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S39A6_HUMAN (81-312): 1.29e-25: 112: 16.60
+	Hs
		410938 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S39AB_HUMAN (129-467): 3.12e-49: 173: 15.04
+	Hs
		410816 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S39A6_HUMAN (81-312): 1.29e-25: 112: 16.60
+	Hs
		710870 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		S39A7_HUMAN (1-469): 8.32e-104: 319: 100.00
+	Hs
		1147396 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		S39A7_HUMAN (1-469): 8.32e-104: 319: 100.00
+	Hs
		710560 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		S39AA_HUMAN (35-469): 2e-86: 284: 21.05
+	Hs
		932099 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		S39AB_HUMAN (129-467): 3.12e-49: 173: 15.04
+	Hs
		710223 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		S39A6_HUMAN (81-312): 1.29e-25: 112: 16.60
+	Hs
		465510 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		S39A6_HUMAN (81-312): 1.29e-25: 112: 16.60